Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Vet Res Commun ; 28(5): 407-13, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15379435

ABSTRACT

Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentrations of 12.72 +/- 5.13 ng/ml for males and 22.65 +/- 11.95 ng/ml for females occurred around 5 days after administration. The area under the concentration-time curve (AUC) was 192.08 +/- 63.85 ng.day/ml for males and 370.97 +/- 146.87 ng.day/ml for females. The mean residence time was the same in males and females (12.55 days). This study reveals a sex-influence on the disposition of selamectin in the plasma of dogs, which implies that further information will be needed for correlation with efficacy studies in dogs.


Subject(s)
Dogs/blood , Ivermectin/analogs & derivatives , Ivermectin/pharmacokinetics , Administration, Topical , Animals , Antiparasitic Agents/administration & dosage , Antiparasitic Agents/blood , Antiparasitic Agents/pharmacokinetics , Female , Half-Life , Ivermectin/administration & dosage , Ivermectin/blood , Male , Metabolic Clearance Rate
SELECTION OF CITATIONS
SEARCH DETAIL
...