Subject(s)
Breast Neoplasms/history , Mastectomy/history , Breast Neoplasms/surgery , Female , France , History, 18th Century , HumansABSTRACT
At the end of the 19th century, uterine fibroids cause huge therapeutic issues: on the one hand they can reach an impressive massive volume; on the other hand they provoke endless haemorrhages. Dr Apostoli develops galvanotherapy which becomes the reference in French and international medicine before its rapid downfall as gynaecological surgery makes great progress at the beginning of the 20th Century.
Subject(s)
Electric Stimulation Therapy/methods , Leiomyoma/therapy , Electric Stimulation Therapy/history , Female , History, 19th Century , Humans , Leiomyoma/historyABSTRACT
The origin of Brussels hospitals goes back to the XIIth century when several institutions created by the Church were only aimed at lodging poor pilgrims. The evolution from ecclesiastic management to municipal direction ended up in the establishment of two main public hospitals devoted to health care : Saint-Jean and Saint-Pierre. The latter, founded under Austrian rule and associated from the start with clinical teaching, gained therefore a prominent position. In 1834, it became a university hospital thanks to an agreement between the recently founded Free University of Brussels and the municipal health authorities. Finally, the administration of the main university clinical infrastructure was totally taken over by the University and moved to the newly erected Erasmus Hospital together with all faculty buildings. Development of the Brussels Maternity occurred rather slowly and underwent several location changes because of varying general politics as well as for sanitary reasons of hygiene. It was not before the XXth century that obstetrical practice progressively shifted from the private domiciliary sphere at the hands of midwives, to the hospital environment and medical control as is the case today.
Subject(s)
Hospitals/trends , Obstetrics and Gynecology Department, Hospital/trends , Belgium , History, 19th Century , Hospitals, Religious/history , Hospitals, Religious/trendsABSTRACT
The Napolean defeat at Waterloo entailed drastic changes of health services in our regions. Under the new Dutch rule, many different medical grades were put in use making the pertinent legal rules very difficult to apply. At Belgian independence, the Free University of Brussels was founded including a Faculty of Medicine of which the clinical infrastructure was mainly the Saint-Pierre Hospital located at the Hal Gate. In 1880, provincial schools for midwives were established while operative obstetrics remained in the hands of general surgeons. At Brussels, medical students rightly complained about the poor training of general practitioners in obstetrics. Until the first third of the XXth century, the vast majority of deliveries took place at home under the supervision of a midwife. A consultant surgeon was called upon only if deemed indispensable.
Subject(s)
Education, Medical/history , Education, Medical/organization & administration , Obstetrics/history , Obstetrics/organization & administration , Belgium , History, 19th Century , Humans , Societies, Medical/historyABSTRACT
As elsewhere in Europe, the origins of Belgian obstetrics are related to the double rivalry between medical doctors and surgeons on the one hand and between surgeons and midwives on the other hand. Extension of obstetrical teaching in our regions has been hampered because of political turmoil resulting from the successive territorial dominations by Spain, Austria, France and Holland. In this evolution, the organisational sanitary model emerging from the French revolution exerted a prominent influence namely through creation of the subordinate grade of "Health Officer" and the suppression of local medical colleges as well as of the sole existing university faculty of medicine. These factors explain the poor quality of obstetrics which has prevailed on our soil until 1815.
Subject(s)
Obstetrics/history , Belgium , History, 17th Century , History, 18th Century , History, 19th Century , Obstetrics/education , Obstetrics/organization & administrationABSTRACT
Calcifications are uncommon in metastases. Adenocarcinoma, osteopenic, osteosarcoma, lung and breast carcinoma can be the origin. A rare case of calcified cystic brain metastasis deriving from papillary cystadenocarcinoma is reported.
Subject(s)
Calcinosis/pathology , Cerebellar Neoplasms/pathology , Cystadenocarcinoma, Papillary/pathology , Aged , Calcinosis/diagnosis , Cerebellar Neoplasms/secondary , Cystadenocarcinoma, Papillary/diagnosis , Cystadenocarcinoma, Papillary/secondary , Female , Humans , Magnetic Resonance Imaging , Tomography, X-Ray ComputedABSTRACT
We report on two sibs with Dandy-Walker malformation and tetramelic postaxial polydactyly. We conclude that this is a new autosomal recessive syndrome.
Subject(s)
Dandy-Walker Syndrome/genetics , Fingers/abnormalities , Hydrocephalus/genetics , Dandy-Walker Syndrome/diagnosis , Diagnosis, Differential , Female , Genes, Recessive , Humans , Infant, Newborn , Male , PregnancyABSTRACT
In this report we summarize the results of a genetic-diagnostic survey of an institutionalized population of 158 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention to dysmorphology and neurological findings. In 72 patients a constitutional cause of their mental impairment was found: a chromosomal abnormality in 21, a Mendelian disorder in 36 (autosomal recessive disorder: 23; autosomal dominant: 12; and X-linked recessive: 1), a MCA/MR syndrome in 9, and a CNS malformation in 6 patients. In 33 patients, a pre- or perinatal cause was found, and 20 patients presented a pre- or perinatal infection of the CNS. Finally, no etiological diagnosis was detected in 28 patients; 6 of them presented a hitherto unclassifiable type of familial mental retardation.
Subject(s)
Chromosome Aberrations/genetics , Institutionalization , Intellectual Disability/genetics , Adolescent , Adult , Belgium , Child , Child, Preschool , Chromosome Disorders , Down Syndrome/genetics , Fragile X Syndrome/genetics , Genes, Dominant , Genes, Recessive , Humans , KaryotypingSubject(s)
Huntington Disease/diagnosis , Adolescent , Adult , Child , Electromyography , Female , Follow-Up Studies , Humans , Huntington Disease/physiopathology , Male , Middle Aged , RiskABSTRACT
A double-blind, placebo-controlled, crossover trial was carried out in 29 patients with Huntington's chorea to evaluate the effectiveness and tolerance of high doses of tiapride in the management of neurological symptoms. Patients were allocated at random into 3 groups to receive 3 g tiapride daily for two periods of 3 weeks either preceded, interrupted or followed by a 3-week period on placebo. Patients were assessed on entry and at the end of each treatment period using a battery of tests designed to measure choreatic movements, motor skills, recognition and reaction times, and mental state. Twenty-three patients completed the trial; only 2 of the 6 drop-outs withdrew because of drug-related side-effects (sedation and extrapyramidal signs). The results showed that tiapride treatment significantly improved choreatic movements and motor skills and these findings were supported by the objective psychometric measurements. Overall evaluation of effectiveness by the physician and patients indicated the significant superiority of tiapride over placebo. Treatment was generally well tolerated and although there were significantly more reports of sedation and extrapyramidal signs whilst patients were receiving tiapride, these effects were rated as mild in most cases and did not interfere with treatment.
Subject(s)
Benzamides/therapeutic use , Huntington Disease/drug therapy , Tiapamil Hydrochloride/therapeutic use , Clinical Trials as Topic , Double-Blind Method , Drug Tolerance , Female , Humans , Male , Middle Aged , Motor Skills/drug effects , Psychological Tests , Psychomotor Performance/drug effects , Random Allocation , Tiapamil Hydrochloride/administration & dosage , Tiapamil Hydrochloride/adverse effects , Wakefulness/drug effectsABSTRACT
Triploid-diploid mosaicism in fibroblasts of a deeply mentally retarded 21-year-old female is reported. The relevant findings in 2n/3n mosaicism are reviewed and discussed.
Subject(s)
Diploidy , Intellectual Disability/genetics , Adult , Chromosome Aberrations/genetics , Chromosome Disorders , Female , Humans , MosaicismABSTRACT
A paracentric inversion of the short arm of chromosome 1 (inv(1)(p22p36)) is reported in a deeply mentally retarded 19-year-old girl and in her normal father.
Subject(s)
Chromosome Inversion , Chromosomes, Human, 1-3 , Intellectual Disability/genetics , Adult , Chromosome Banding , Female , Humans , Karyotyping , Male , Middle AgedABSTRACT
A 21-year-old mentally retarded female with 10p12 trisomy is reported. She presented a slight craniofacial dysmorphism very similar to that found in the full 10p-trisomy syndrome. Other features usually found in full 10p trisomy, however, such as failure to thrive and internal malformations, were absent.
Subject(s)
Chromosomes, Human, 6-12 and X , Intellectual Disability/genetics , Trisomy , Adult , Face/abnormalities , Female , Humans , KaryotypingSubject(s)
Huntington Disease/pathology , Adult , Aged , Cell Adhesion , Cell Division , Cell Survival , Cells, Cultured , Culture Media , Female , Fibroblasts/drug effects , Fibroblasts/immunology , Fibroblasts/pathology , Hot Temperature , Humans , Huntington Disease/immunology , Immune Sera , Insulin/pharmacology , Male , Middle Aged , Skin/pathology , Surface PropertiesABSTRACT
A 10-year-old girl with partial deletion of the short arm of chromosome 9 is reported; karyotype: 46,XX,del(9)(p22). This syndrome results in a distinctive craniofacial dysmorphism with trigonocephaly and contrasting midfacial hypoplasia. Partial monosomy 9p was the result of a paternal de novo germinal deletion in this case.
Subject(s)
Chromosome Deletion , Chromosomes, Human, 6-12 and X , Intellectual Disability/genetics , Child , Chromosomes, Human/ultrastructure , Female , Humans , Karyotyping , PhenotypeSubject(s)
Tuberous Sclerosis/diagnosis , Child , Child, Preschool , Humans , Tuberous Sclerosis/pathologyABSTRACT
A large kindred is described in which 22 males and 3 females show non-specific mental retardation with impaired speech. An X-linked recessive is the most likely mode of inheritance of this condition. Similar families have been described in the literature, characteristic physical abnormalities are absent and performance I.Q. tends to be higher than verbal I.Q. This possible heterogenous condition may be a major individual cause of mental deficiency in males, and may account for the excess of male retardates in the population.
Subject(s)
Genes, Recessive , Intellectual Disability/genetics , Sex Chromosomes , Speech Disorders/genetics , X Chromosome , Adolescent , Adult , Aged , Child , Child, Preschool , Chromosomes, Human, 6-12 and X , Female , Humans , Intellectual Disability/diagnosis , Male , Middle Aged , Pedigree , Speech Disorders/diagnosisABSTRACT
A possibly new mental retardation syndrome is described in a large family. The major features of the syndrome are: short statue, craniofacial dysmorphism and dento-skeletal abnormalities. The mode of inheritance of this syndrome appears to be autosomal dominant with a variable degree of expressivity. The possible similarity to another autosomally dominant inherited mental retardation syndrome, "the K.B.G. syndrome" as described by Hermann et al. (1975), is discussed.