Subject(s)
Histocompatibility Antigens , Lymphocytes/immunology , Macaca/immunology , Rh-Hr Blood-Group System , Animals , Antibody Formation , Antibody Specificity , Blood Platelets/immunology , Complement Fixation Tests , Cross Reactions , Cytotoxicity Tests, Immunologic , Female , Genotype , Graft Rejection , Haplorhini , Histocompatibility , Histocompatibility Testing , Immune Sera , Immunization , Leukocytes/immunology , Male , Methods , Phenotype , Tissue Survival , Transplantation, HomologousSubject(s)
Histocompatibility Testing , Transplantation Immunology , Animals , Antibody Formation , Bone Marrow Transplantation , Cytotoxicity Tests, Immunologic , Genotype , Graft Rejection , Graft vs Host Reaction , Haplorhini , Humans , Immune Sera , Kidney Transplantation , Macaca , Phenotype , Rh-Hr Blood-Group System , Skin Transplantation , Transplantation, HomologousSubject(s)
Histocompatibility Testing , Immune Sera , Absorption , Animals , Antibody Specificity , Blood Platelets/immunology , Cytotoxicity Tests, Immunologic , Erythrocytes/immunology , Hemagglutination Inhibition Tests , Hemagglutination Tests , Humans , Isoantibodies , Lymphocytes/immunology , Pan troglodytes , Skin Transplantation , Transplantation, HomologousSubject(s)
Antigens/classification , Hominidae/immunology , Leukocytes/immunology , Transplantation Immunology , Agglutination Tests , Animals , Antibody Specificity , Cytotoxicity Tests, Immunologic , Histocompatibility Testing , Humans , Immune Sera , Immunogenetics , Isoantibodies/analysis , Species SpecificitySubject(s)
Histocompatibility Antigens , Leukocytes/immunology , Animals , Biological Evolution , Complement Fixation Tests , Cytotoxicity Tests, Immunologic , Epitopes , Graft Rejection , Haplorhini , Hemagglutination Tests , Histocompatibility Testing , Humans , Immune Sera , Isoantibodies/analysis , Lymphocytes/immunology , Macaca , Pan troglodytes , Skin TransplantationSubject(s)
Antilymphocyte Serum/adverse effects , Immune Tolerance , Serum Globulins/administration & dosage , Transplantation Immunology , Anaphylaxis , Animals , Antibodies/analysis , Antibody Formation , Antilymphocyte Serum/isolation & purification , Azathioprine/pharmacology , Chromatography , Erythrocytes/immunology , Female , Haplorhini , Horses , Immunoelectrophoresis , Male , Serum Globulins/isolation & purification , Sheep , Skin Transplantation , Transplantation, Homologous , UltracentrifugationSubject(s)
Antilymphocyte Serum/pharmacology , Haplorhini , Hemagglutination Tests , Hominidae , Immunosuppressive Agents/pharmacology , Transplantation Immunology/drug effects , Animals , Histocompatibility/drug effects , Horses , Lymphocytes/immunology , Methods , Skin Transplantation , Species SpecificitySubject(s)
Antilymphocyte Serum/standards , Immunosuppression Therapy , Animals , Antilymphocyte Serum/isolation & purification , Antilymphocyte Serum/therapeutic use , Blood Platelets/immunology , Cytotoxicity Tests, Immunologic , Erythrocytes/immunology , Haplorhini , Hemagglutination Tests , Horses , Humans , Immune Adherence Reaction , Immunization Schedule , Immunoglobulins/analysis , Leukemia, Lymphoid/immunology , Lymph Nodes/immunology , Lymphocytes/immunology , Macaca , Models, Biological , Nitrobenzenes , Pan troglodytes , Precipitins/analysis , Serum Globulins , Skin Tests , Skin Transplantation , Species Specificity , Spleen/immunology , Thoracic Duct/cytology , Thymus Gland/immunology , Transplantation Immunology , Transplantation, HomologousSubject(s)
Isoantibodies , Leukocytes/immunology , Transplantation Immunology , Animals , Female , Hominidae , Immunoassay , Male , Skin Transplantation , Transplantation, HomologousABSTRACT
Methylcholanthrene was administered intradermally to adult normal and neonatally thymectomized mice. The incidence, latency period, growth rate, and histological type of the developing tumors were not significantly different for thymectomized mice as compared with those for controls. The antigenicity of the tumors varied in both groups, but the percentage of strongly antigenic tumors was unequivocally higher in thymectomized mice. Other investigators demonstrated a clearly increased susceptibility of thymectomized rodents to the carcinogenic effect of benzopyrene and to certain tumor viruses. They postulated that an enhanced incidence of the mostly antigenic tumors is related to the impairment of immune reactivity after early thymectomy. To test this hypothesis, we determined the immune reactivity of each individual thymectomized mouse by grafting homologous skin before administering the carcinogen. Thymectomized mice with normal homograft reactivity were thus distinguishable from those with depressed reactivity. Surprisingly, tumor incidence in the latter group was, if anything, lower than in the immunologically competent animals. It is plausible that immunological depression as a consequence of thymectomy promotes the establishment of antigenic tumors; on the other hand, the growth conditions for tumors, particularly for the less antigenic variety, may not be ideal in thymectomized mice.