ABSTRACT
The present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. Solid lipid nanoparticulate delivery system of cisplatin has been developed by microemulsification method by using stearic acid, soy lecithin 95% and sodium glycolate. The formulations were then characterized with respect to size and its surface morphology, zeta potential, entrapment efficiency, in vitro drug release profile, in vivo drug targeting studies and its stability under specific conditions. The formulated solid lipid nanoparticles were oval with a diameter ranging from 250 nm to 500 nm. The lowest entrapment efficiency was found to be 47.59% and highest was found to be 74.53%. The zeta potential was in the range of -9.8 to -11.2 mv. In vitro release study was analyzed using various mathematical models. Highest cumulative percent drug release was observed with F-1 (97.22 %) and lowest with F-4 (78.43%) in 16 h. The in vivo result of formulated solid lipid nanoparticles of cisplatin reveals that the drug is preferentially targeting to liver followed by brain and lungs.
Subject(s)
Finger Injuries/diagnostic imaging , Joint Dislocations/diagnostic imaging , Adult , Athletic Injuries/diagnostic imaging , Athletic Injuries/etiology , Athletic Injuries/surgery , Female , Finger Injuries/etiology , Finger Injuries/surgery , Humans , Joint Dislocations/etiology , Joint Dislocations/surgery , Male , RadiographyABSTRACT
Volar dislocations of the proximal interphalangeal joint, if missed, with extensor tendon entrapment will lead to permanent impairment. Prompt diagnosis followed by open reduction and aggressive rehabilitation is necessary.
Subject(s)
Finger Joint/diagnostic imaging , Finger Joint/pathology , Joint Dislocations/diagnosis , Tendon Injuries/diagnosis , Adult , Diagnostic Errors , Female , Finger Joint/surgery , Humans , Joint Dislocations/surgery , Male , Radiography , Tendon Injuries/surgeryABSTRACT
Embedding ring injury is a very rare injury. Patients will mental illness should be considered at risk.
Subject(s)
Fingers/surgery , Foreign Bodies/surgery , Adult , Foreign Bodies/complications , Humans , Male , Mental Disorders/complicationsABSTRACT
Isolated radial head fractures, which are rare, comprise about 2% of all fractures around the elbow. A case is reported of bilateral radial head fracture in an international female athlete. Early recognition and aggressive rehabilitation is essential if an abrupt end to a promising sporting career is to be prevented.
Subject(s)
Martial Arts/injuries , Radius Fractures/diagnosis , Adult , Female , Humans , Radiography , Radius Fractures/diagnostic imagingABSTRACT
We report an unusual presentation of delayed subcutaneous emphysema of the thigh following arthroscopy with a fluid medium, which was managed conservatively. This rare presentation must be recognised by all orthopaedic surgeons practising arthroscopic surgery.
Subject(s)
Arthroscopy/adverse effects , Knee Joint/surgery , Postoperative Complications , Subcutaneous Emphysema/etiology , Humans , Male , Middle Aged , Radiography , Subcutaneous Emphysema/diagnostic imaging , Thigh/diagnostic imagingABSTRACT
Two newborns with history of difficult birth were diagnosed within 24 hours after birth with isolated radial nerve palsy. Both newborns recovered completely. Awareness and multidisciplinary approach is essential.
