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1.
J Biotechnol ; 343: 62-70, 2022 Jan 10.
Article in English | MEDLINE | ID: mdl-34838616

ABSTRACT

Presence of methanotrophs in diverse environmental habitats helps to reduce emissions of greenhouse gas like methane. Isolation and culture of undiscovered wealth of methanotrophic organisms can help in exploitation of these organisms in value added products. The present study focuses on the enrichment of methanotroph dominated mixed microbial community by use of three stage strategy of revival, proliferation, and segregation. During the enrichment process amplicon sequencing of 16 s rRNA V3-V4 region showed relative abundance of mixed culture comprising single methanotrophic species of Methylocystis genus (88.92%) along with only three other species. Methylocystis dominant mixed culture (MMI-11) was observed to produce polyhydroxyalkanoates (PHA). During studies to identify favourable culture conditions, nitrate was found to be preferred nitrogen source for growth and PHA production. Cell growth ability to produce PHA was also evaluated at 14 L fermentor by supplying gas using continuous bubbling and through pressurization in the headspace. The mixed methanotrophic culture was found to accumulate maximum of 22.20% polyhydroxybutyrate (PHB) under nitrate limited condition. The molecular weight of PHB was found to be 2.221 × 105 g mol-1 with polydispersity of 1.82.


Subject(s)
Methylocystaceae , Oryza , Polyhydroxyalkanoates , Bioreactors , Methane
2.
Nucleic Acids Res ; 44(D1): D385-95, 2016 Jan 04.
Article in English | MEDLINE | ID: mdl-26476444

ABSTRACT

The Protein Data Bank in Europe (http://pdbe.org) accepts and annotates depositions of macromolecular structure data in the PDB and EMDB archives and enriches, integrates and disseminates structural information in a variety of ways. The PDBe website has been redesigned based on an analysis of user requirements, and now offers intuitive access to improved and value-added macromolecular structure information. Unique value-added information includes lists of reviews and research articles that cite or mention PDB entries as well as access to figures and legends from full-text open-access publications that describe PDB entries. A powerful new query system not only shows all the PDB entries that match a given query, but also shows the 'best structures' for a given macromolecule, ligand complex or sequence family using data-quality information from the wwPDB validation reports. A PDBe RESTful API has been developed to provide unified access to macromolecular structure data available in the PDB and EMDB archives as well as value-added annotations, e.g. regarding structure quality and up-to-date cross-reference information from the SIFTS resource. Taken together, these new developments facilitate unified access to macromolecular structure data in an intuitive way for non-expert users and support expert users in analysing macromolecular structure data.


Subject(s)
Databases, Protein , Protein Conformation , Internet , Microscopy, Electron , Models, Molecular , User-Computer Interface
3.
J Cancer Res Ther ; 8 Suppl 1: S94-9, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22322738

ABSTRACT

AIM: This study aims to provide information on the accrual rate and to identify the reasons for non-enrollment of oral cancer patients into a clinical trial. SETTING AND DESIGN: Prospective study conducted at the Tertiary Cancer Centre (India). MATERIALS AND METHODS: Patients eligible and screened for the oral cancer adjuvant therapy (OCAT) were logged prospectively and reasons for non-enrollment were documented which were broadly divided into patient and trial related. STATISTICAL ANALYSIS USED: Demographic characteristics of the non-enrolees were compared with the enrolled. Factors predicting non-enrollment were analyzed using multivariate logistic regression test. RESULTS: A total of 1335 patients with locally advanced cancer of the oral cavity were screened of whom 498 (37%) could be enrolled. Among non enrolled 837 patients, 182 (22%) had the trial-related reasons and 655 (78%) had patient-related reasons. Most important patient-related reasons were patients' preference of taking treatment closer to their native place (26.2%), lack of interest (16.8%) in trial participation. Anticipated poor compliance to treatment (5.9%) and follow-up (6.6%), inability to start treatment in time (6.2%) were important trial-related reasons for non-enrollment. Multivariate analysis identified the genders (female), education (illiterate), occupation (laborer) and non availability of support system in the city as significant predictors of non-enrollment. CONCLUSIONS: Both trial design and patient factors were important causes of non enrollment in eligible patients. Patients' need for being closer to home and refusal to participate were the most common reasons for non-enrollment.


Subject(s)
Mouth Neoplasms/drug therapy , Patient Preference , Patient Selection , Research Design , Antineoplastic Agents/therapeutic use , Chemotherapy, Adjuvant , Female , Humans , Male , Middle Aged
4.
Eur Arch Otorhinolaryngol ; 267(7): 1135-40, 2010 Jul.
Article in English | MEDLINE | ID: mdl-20066453

ABSTRACT

The objective of the article is to study the prognostic indicators of loco-regional failure in patients with early stage cancers of the gingivobuccal complex (GBC) treated at a single institution. The study design is based on retrospective chart review. A review of 2,275 patients diagnosed with GBC was conducted from January 1997 to December 1999, wherein 207 patients who fulfilled our inclusion criteria were analyzed. Univariate analysis, multivariate analysis, and disease-free survival are reported. During a median follow-up of 2.85 years there were 85 (43%) loco-regional failures of which 64% could be salvaged. As much as 80% of all failures occurred within the first 24 months and the mean survival for patients with recurrences was 9.6 months. Two and five-year disease-free survival for the entire cohort was 65% and 52%, respectively. Nodal metastasis, soft tissue infiltration, and pathological bone involvement correlated with poor disease-free survival on multivariate analysis. Early stage tumors of the GBC as evaluated clinically are often upstaged pathologically due to a high rate of occult nodal metastasis and local failure as they tend to invade bone and infiltrate adjacent soft tissue. Consequently, we recommend aggressive surgical therapy as we would recommend for advanced stage cancers of the GBC which includes a wide three-dimensional resection to account for soft tissue and bony infiltrations and adjuvant therapy in the presence of adverse features since salvage rates for recurrent tumors are poor.


Subject(s)
Carcinoma, Squamous Cell/pathology , Mouth Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/surgery , Disease-Free Survival , Female , Gingival Neoplasms/pathology , Humans , Lymphatic Metastasis , Male , Middle Aged , Mouth Neoplasms/surgery , Neoplasm Recurrence, Local , Neoplasm Staging , Prognosis , Proportional Hazards Models , Retrospective Studies
5.
Am J Otolaryngol ; 30(3): 176-80, 2009.
Article in English | MEDLINE | ID: mdl-19410123

ABSTRACT

PURPOSE: Head and neck cancer (HNC) survivors have substantial psychological distress in addition to treatment-related side effects. This study examines the long-term quality of life (QOL) of HNC survivors in a busy tertiary care center. MATERIAL AND METHODS: A prospective, cross-sectional survey was conducted studying 212 HNC survivors 1 year after completion of their treatment at a tertiary cancer center. Quality of life assessments were performed using the 2 standardized health-related QOL questionnaires: The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and The Quality of Life Questionnaire Head and Neck Cancer Module. RESULTS: The overall global QOL rating for the study cohort was satisfactory. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 scores showed that the domains where most patients faired poorly included financial difficulties (54%), appetite loss (36%), fatigue (33%), and cough (30%). The Quality of Life Questionnaire Head and Neck Cancer Module scale identified the domains with poor scores to be dry mouth (64%), dental problems (42%), sticky saliva (40%), cough (39%), and problems with mouth opening (32%). Patients with early-stage tumors and those treated with surgery alone had significantly better QOL scores when compared with advanced stage tumors and patients receiving either radiation alone or multimodality treatment, respectively. CONCLUSIONS: Quality of life questionnaires provide a medium for patients to effectively communicate with their physician in a busy tertiary care facility and provide an insight into the physical, psychological, and social problems affecting our patients which can then direct future interventions.


Subject(s)
Head and Neck Neoplasms/complications , Head and Neck Neoplasms/psychology , Psychometrics , Quality of Life/psychology , Survivors/psychology , Adolescent , Adult , Aged , Aged, 80 and over , Combined Modality Therapy , Cross-Sectional Studies , Female , Head and Neck Neoplasms/physiopathology , Head and Neck Neoplasms/therapy , Humans , Male , Middle Aged , Neoplasm Staging , Prospective Studies , Statistics, Nonparametric , Surveys and Questionnaires , Young Adult
6.
Head Neck ; 31(5): 618-24, 2009 May.
Article in English | MEDLINE | ID: mdl-19132717

ABSTRACT

BACKGROUND: The aim of this study is to determine the need for a randomized controlled trial in order to define the role of an elective neck dissection (END) in the treatment of early tongue cancers. METHODS: We present a large retrospective analysis of patients with T1-2 N0 squamous cell cancers of the oral anterior tongue treated at a single institution. A total of 359 eligible patients with early tongue cancers were divided into 2 groups: END and wait and watch (WW). An analysis for survival outcomes and prognostic factors was conducted. RESULTS: The estimated 3- and 5-year disease-free survival for the END group was 76% and 74% versus 71% and 68% for the WW group, respectively (p = .53). The 3- and 5-year overall survival (OS) rate for the END group was 69% and 60% versus 62% and 60% for the WW group, respectively (p = .24). Tumor grade and perineural invasion were independent predictors of recurrence. CONCLUSION: END did not impact disease-free or OS. Current literature still remains divided on this issue emphasizing the need for a randomized controlled trial.


Subject(s)
Carcinoma, Squamous Cell/therapy , Elective Surgical Procedures , Neck Dissection , Tongue Neoplasms/therapy , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/pathology , Decision Making , Female , Humans , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Recurrence, Local , Prognosis , Radiotherapy, Adjuvant , Randomized Controlled Trials as Topic , Retrospective Studies , Survival Analysis , Tongue Neoplasms/mortality , Tongue Neoplasms/pathology
7.
Oral Oncol ; 45(1): 47-51, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18620896

ABSTRACT

This paper studies the clinical and pathological predictors of local recurrence and disease-free survival (DFS) in patients with oral verrucous carcinoma (OVC) treated surgically, through a retrospective chart review. Three hundred and two patients with OVC were identified from January 1990 to December 2000, of which, 101 surgically treated patients who fulfilled our inclusion criteria were analyzed. A univariate analysis (UVA) of important prognostic factors, patterns of recurrence, and DFS is reported. Seventy-nine patients were male (M:F ratio, 3.6:1) and the mean age at presentation was 53.9 years (range, 23-90 years). The median follow up was 4.61 years (range, 0.51-14.3 years). The incidence of tobacco chewing, smoking, and alcohol intake was 77%, 42%, and 10%, respectively. Thirty-four patients (33.7%) had either leukoplakia or submucous fibrosis (SMF) on oral cavity examination. Early-stage tumors accounted for 39.7%; while 60.4% were late-stage tumors. On UVA, tumor location, presence of a premalignant lesion, smoking, and positive margins were statistically significant. Sixty-eight percent (19/28) recurred locally. The salvage rate for recurrent tumors was 66.7% (16/28) with a median post-recurrence survival of 16 months (range, 10-83 months). The five year DFS with surgical therapy was 77.6%. OVC has an excellent prognosis with surgical treatment. The significance of positive margins emphasizes the need for adequate surgical resection. Additionally, the presence of either leukoplakia or SMF and tumor location in the upper alveolar-palatal complex is associated with worse outcomes. Neck dissection, if considered, may be limited to a supra-omohyoid neck dissection (SOHND).


Subject(s)
Carcinoma, Verrucous/pathology , Mouth Mucosa/pathology , Mouth Neoplasms/pathology , Neoplasm Recurrence, Local/pathology , Tobacco Use Disorder/pathology , Adult , Aged , Aged, 80 and over , Carcinoma, Verrucous/surgery , Disease-Free Survival , Female , Fibrosis , Humans , Leukoplakia, Oral/pathology , Male , Middle Aged , Mouth Neoplasms/surgery , Neck Dissection , Neoplasm Recurrence, Local/surgery , Prognosis , Retrospective Studies , Tobacco Use Disorder/surgery , Young Adult
8.
Oral Oncol ; 45(2): 135-40, 2009 Feb.
Article in English | MEDLINE | ID: mdl-18621571

ABSTRACT

The purpose of our study was to analyze the indicators of loco-regional failure in a large cohort of patients with gingivobuccal complex tumors treated at a single institution. A retrospective review of 2275 patients diagnosed with tumors of the gingivobuccal complex was conducted from January 1997 to December 1999; 642 patients who fulfilled our inclusion criteria were analyzed. A univariate analysis, multivariate analysis, and disease-free survival are reported. During a median follow up of 2.51 years, there were 228 (35.5%) recurrences with a median post-recurrence survival of 2.7 months. The incidence of occult neck metastasis was 29%. The 2- and 5-year DFS rates were 63.8% and 53.3%, respectively. On multivariate analysis, tumor depth and metastatic lymphadenopathy were found to be independent prognostic factors for disease-free survival. Advanced gingivobuccal cancers fail loco-regionally. Cervical metastasis and tumor depth influence disease-free survival. Elective neck dissection due to a high incidence of occult neck disease is recommended.


Subject(s)
Carcinoma, Squamous Cell/pathology , Mouth Neoplasms/pathology , Neoplasm Recurrence, Local/pathology , Adult , Aged , Aged, 80 and over , Analysis of Variance , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/secondary , Cohort Studies , Disease-Free Survival , Female , Gingival Neoplasms/mortality , Gingival Neoplasms/pathology , Humans , Lymphatic Metastasis , Male , Middle Aged , Mouth Neoplasms/mortality , Neoplasm Recurrence, Local/mortality , Neoplasm Staging , Retrospective Studies , Young Adult
9.
Head Neck ; 31(1): 37-44, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18798315

ABSTRACT

BACKGROUND: Voice-related quality of life (V-RQOL) has never been studied in Indian patients. This study was planned to validate and assess V-RQOL in patients using tracheoesophageal puncture (TEP). METHODS: A cross-sectional study was undertaken to validate V-RQOL questionnaire by testing reliability, validity, and responsiveness. V-RQOL was assessed in patients undergoing total laryngectomy with primary TEP. RESULTS: One hundred thirty-two patients filled 188 questionnaires. Analysis was carried out on 122 patients. Reliability and validity of questionnaire were tested by Cronbach's alpha (.84-.91) and item-scale correlation (.67-.86). Median V-RQOL-Total score was 76.2 indicating excellent V-RQOL. Higher scores were observed in patients less than 50 years (82.5 vs 72.5, p = .08). There was no effect of time interval between laryngectomy and assessment of questionnaire on the V-RQOL scores. CONCLUSION: V-RQOL questionnaire can be used reliably to assess V-RQOL, which is found to be excellent in Indian patients undergoing TEP.


Subject(s)
Laryngeal Neoplasms/surgery , Laryngectomy/rehabilitation , Adult , Age Factors , Cross-Sectional Studies , Humans , India , Laryngeal Neoplasms/rehabilitation , Larynx, Artificial , Middle Aged , Punctures , Quality of Life , Reproducibility of Results , Speech, Esophageal , Surveys and Questionnaires , Voice Quality
11.
Nat Clin Pract Oncol ; 4(12): 726-8, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18037877

ABSTRACT

BACKGROUND: A 66-year-old Asian man presented with a tongue ulcer and without palpable metastases to the neck nodes. A thorough clinical examination of the head and neck region did not reveal any other primary lesion. To assess the status of the neck, PET-CT imaging was advised. INVESTIGATIONS: Physical examination, punch biopsy, PET-CT imaging, blood tests, chest radiograph, fine-needle aspiration biopsy, tumor biopsy, neck incision, tuberculin test, sputum culture and histopathology. DIAGNOSIS: Carcinoma of the tongue of pathologic stage T2 N0 M0, with tubercular lymphadenitis and no nodal metastases. MANAGEMENT: Surgical excision and multidrug antitubercular therapy.


Subject(s)
Carcinoma, Squamous Cell/diagnostic imaging , Positron-Emission Tomography , Tongue Neoplasms/diagnostic imaging , Tuberculosis, Lymph Node/diagnostic imaging , Aged , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/secondary , Diagnosis, Differential , Humans , Male , Neoplasm Metastasis/diagnostic imaging , Tongue Neoplasms/complications , Tongue Neoplasms/pathology , Tuberculosis, Lymph Node/complications
12.
Oral Oncol ; 43(8): 774-9, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17306606

ABSTRACT

Squamous cell carcinoma of the superior gingival-buccal complex are rare and few English-language data have been published on their biological behaviour. Reported in this paper are the clinical behaviour and treatment outcomes of squamous cell carcinoma of the upper gingival-buccal complex. We reviewed the charts of 110 patients with squamous cell carcinoma restricted to the upper gingiva, superior gingival-buccal sulcus and adjoining buccal mucosa, seen between 1997 and 2001. Separate outcome analyses were carried out among 86 patients who had undergone surgery, and 24 patients treated by radiotherapy or chemo-radiation. Disease-free survival at 2 and 5 years was 48.9% and 36%, respectively, and was independent of epicentre of disease. Five-year, disease-free survival was 48.8% and 0% for surgical treatment and non-surgical treatment groups. T stage (p=0.024) and extra-capsular spread of disease (p=0.036) were independent predictors of disease-free survival on multivariate analysis. Adequate surgical resection and adjuvant treatment, in the first instance, offers the best chance of disease control.


Subject(s)
Carcinoma, Squamous Cell/pathology , Mouth Neoplasms/pathology , Adult , Aged , Carcinoma, Squamous Cell/secondary , Carcinoma, Squamous Cell/surgery , Carcinoma, Squamous Cell/therapy , Cell Differentiation , Combined Modality Therapy , Epidemiologic Methods , Female , Gingival Neoplasms/pathology , Gingival Neoplasms/surgery , Gingival Neoplasms/therapy , Humans , Lymphatic Metastasis , Male , Maxilla/surgery , Middle Aged , Mouth Mucosa , Mouth Neoplasms/surgery , Mouth Neoplasms/therapy , Neoplasm Staging , Prognosis , Treatment Outcome
13.
J Surg Oncol ; 94(3): 257-9, 2006 Sep 01.
Article in English | MEDLINE | ID: mdl-16900521

ABSTRACT

Cancer of buccal gingival sulcus lie in close proximity to mandible but tend to invade bone late in the course of disease. Segmental mandibulectomy advocated for these tumors results in cosmetic disfigurement and functional impairment. We, for the first time, describe a mandibular preservation alternative, in form of buccal cortical plate excision, for these tumors.


Subject(s)
Gingival Neoplasms/surgery , Mandible/surgery , Mouth Mucosa/surgery , Oral Surgical Procedures/methods , Cheek , Gingival Neoplasms/pathology , Humans , Mandibular Neoplasms/secondary
15.
Oral Oncol ; 42(8): 837-41, 2006 Sep.
Article in English | MEDLINE | ID: mdl-16730221

ABSTRACT

Selective neck dissection (I-III) for oral cancers offers similar regional control rates with less morbidity as compared with modified radical neck dissection. Charts of 414 patients with oral cancer, who underwent selective neck dissection (I-III) during 1994-2001, were analysed retrospectively. Seventy nine percent of the patients had a primary tumour in the gingivo-buccal complex. Cancer of tongue showed a trend towards higher regional failure (12.3%) as compared to gingivo-buccal cancers (6.5%). Primary tumour was staged as T1-8%, T2-47%, T3-19% and T4-26%. Sixty five percent of the patients were clinically node negative. Isolated neck failure was observed in 4.8% of patients at 2 years and in 5.8% at 5 years. De-differentiation of primary tumour and perineural spread were associated with regional failures. Eighty three percent of the neck recurrences were in the ipsilateral neck and only 16% of these were at levels IV or V. In all, 30% of all regional failures were outside the field of dissection.


Subject(s)
Mouth Neoplasms/pathology , Neck Dissection/methods , Adult , Aged , Aged, 80 and over , Cell Differentiation , Epidemiologic Methods , Female , Humans , Lymphatic Metastasis , Male , Middle Aged , Mouth Neoplasms/therapy , Neoplasm Recurrence, Local , Neoplasm Staging , Prognosis , Salvage Therapy , Tongue Neoplasms/pathology , Tongue Neoplasms/therapy , Treatment Failure , Treatment Outcome
16.
Head Neck ; 27(7): 597-602, 2005 Jul.
Article in English | MEDLINE | ID: mdl-15825204

ABSTRACT

BACKGROUND: Carcinoma of the gingivobuccal complex is commonly associated with the use of smokeless tobacco known as "quid." METHODS: We conducted a retrospective chart review of 511 patients with advanced cancer of gingivobuccal complex surgically treated during 1994 to 1995. We evaluated patterns of disease failure in these patients and correlated disease-free survival with various prognostic factors. RESULTS: During a median follow-up of 46 months, 159 locoregional recurrences and 11 distant metastases were detected in 148 patients. Seventy-nine percent of the recurrences appeared within 18 months of surgery, and the median survival for patients with recurrent disease was less than 4 months. Two-year and 5-year disease-free survival rates were 64% and 57%, respectively. On multivariate analysis, disease-free survival showed significant correlation with skin involvement and extracapsular spread. CONCLUSIONS: Gingivobuccal cancers usually fail locoregionally. Soft tissue infiltration and extracapsular spread of nodal disease influence disease-free survival.


Subject(s)
Carcinoma, Squamous Cell/pathology , Mouth Neoplasms/pathology , Neoplasm Recurrence, Local/pathology , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/secondary , Disease-Free Survival , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Mouth Neoplasms/mortality , Multivariate Analysis , Neoplasm Recurrence, Local/mortality , Prognosis , Retrospective Studies
17.
J Surg Oncol ; 86(2): 105-6, 2004 May 01.
Article in English | MEDLINE | ID: mdl-15112253

ABSTRACT

A good reconstruction should not only be functionally and aesthetically sound at the recipient site but also cause least possible cosmetic aberration of the donor site. The pectoralis major myocutaneous (PMMC) flap continues to be one of the most commonly used flap for head and neck reconstruction in this part of the world. Conventionally, once the skin paddle over the pectoralis major muscle is marked, a line is drawn joining the outer edge of the skin flap extending to the apex of the anterior axillary skin fold or midclavicular point to expose the underlying pectoralis major muscle and harvest the flap. We intend to suggest a novel technique, in which the pectoralis major muscle is exposed by raising the skin around the skin paddle incision alone without making any further extension.


Subject(s)
Pectoralis Muscles/transplantation , Plastic Surgery Procedures/methods , Skin Transplantation/methods , Surgical Flaps , Dermatologic Surgical Procedures , Female , Head and Neck Neoplasms/surgery , Humans , Pectoralis Muscles/blood supply
18.
J Surg Oncol ; 86(1): 41-3, 2004 Apr 01.
Article in English | MEDLINE | ID: mdl-15048679

ABSTRACT

The surgical treatment in early cancers of the lower gingivobuccal (GB) complex involves wide resection of the buccal mucosa and GB sulcus with or without marginal mandibulectomy. To reconstruct this defect we endeavour to describe a method of advancement of the lateral floor of mouth and tongue to provide pliable, vascularised tissue to bridge the mucosal defect and achieve tension free, primary closure whilst preserving maximum tongue mobility and maintaining adequate mouth opening, thus offering an elegant and simple solution to the problems of reconstruction in early lesions of the lower gingivo buccal complex.


Subject(s)
Mouth Neoplasms/surgery , Oral Surgical Procedures/methods , Cheek/surgery , Humans , Mandible/surgery , Mouth Floor/surgery , Surgical Flaps/blood supply , Tongue/surgery
20.
Ann Thorac Cardiovasc Surg ; 9(4): 264-5, 2003 Aug.
Article in English | MEDLINE | ID: mdl-13129427

ABSTRACT

Thoracic duct cysts of the mediastinum are extremely rare. The etiology may be related to a congenital or degenerative weakness in the wall of the thoracic duct. They are generally asymptomatic but may sometimes cause pressure effects on adjacent structures. Imaging studies are supportive but not diagnostic. Excision of these cysts is required for diagnosis and to prevent complications. We describe a 49-year old man who presented to us with hoarseness and a fixed right vocal cord. Computed tomography (CT) showed a cystic posterior mediastinal mass in the right paratracheal region. We performed a posterolateral thoracotomy and found the cyst arising from the thoracic duct and contained chylous fluid with a high lipid concentration. We dissected the cyst from the surrounding structures and excised it. Histopathology revealed a cyst lined by a single layer of endothelial cells. He is asymptomatic now one year after surgery.


Subject(s)
Mediastinal Cyst/diagnostic imaging , Thoracic Duct/diagnostic imaging , Humans , Male , Mediastinal Cyst/surgery , Middle Aged , Radiography , Thoracic Duct/surgery
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