The role of spectral-domain optical coherence tomography in the diagnosis of retinal angiomatous proliferation.

BACKGROUND: We present the findings of spectral-domain optical coherence tomography (OCT) in 8 patients with retinal angiomatous proliferation. HISTORY AND SIGNS: Eight patients with a known history of age-related macular degeneration presented with a recent decrease of visual acuity in one eye. On fundus examination, all patients showed an elevated macular lesion associated with intra- or subretinal hemorrhage and retinal hard exudates. Fluorescein and indocyanine-green (ICG) angiography, together with spectral-domain OCT (Optopol Copernicus SOCT), were performed. THERAPY AND OUTCOME: Fluorescein angiography showed early hyperfluorescence with late leakage in all cases. A serous pigment epithelium detachment was present in 6 cases. ICG angiography showed a hot spot in the macular area. The OCT showed a serous pigment epithelium detachment in 6 cases and intraretinal cysts in all cases. The line crossing the ICG visible hot spot showed a greatly hyperreflective intraretinal lesion located at various depths inside the retina. CONCLUSIONS: Spectral-domain OCT is a useful complementary tool to confirm the diagnosis of retinal angiomatous proliferation. Its high resolution and speed enables accurate localization of the angiomatous lesion.

Spectral optical coherence tomography findings in adult-onset foveomacular vitelliform dystrophy.

BACKGROUND: Adult-onset foveomacular vitelliform dystrophy (AOFVD) is typically bilateral and symmetrical. We present the spectral optical coherence tomography (OCT) findings in two patients with unilateral AOFVD. PATIENTS AND METHODS: Case 1 represents a 76-year-old man followed angiographically over the last 6 years for a macular lesion in his right eye. Visual acuity in the right eye has decreased from 1.0 to 0.6. In case 2, a 69-year-old man presented with blurred vision in his right eye. Visual acuity was 0.7 in the right eye and 1.0 in the left eye. In both patients, spectral OCT (Copernicus SOCT System) was performed. RESULTS: In case 1, fluorescein angiography showed a juxtafoveal hyperfluorescent lesion 2 / 3 of disc area in size, without late leakage. OCT showed a cystic oval lesion with thick walls, located between the retinal pigment epithelium (RPE) and photoreceptor layers. In case 2, OCT showed a hyperreflective round lesion also located between the RPE and photoreceptor layers, elevating the overlying inner retina. CONCLUSIONS: Spectral OCT enables enhanced visualization of the retinal layers and provides useful information regarding the diagnosis and the exact location of AOFVD.