ABSTRACT
Canine transmissible venereal tumour (CTVT) is a contagious cancer spread by transfer of living cancer cells. Occasional cases are observed in the UK in dogs imported from endemic regions. Here, we report a case of imported canine transmissible venereal tumour that was transmitted to a second dog within the UK. Transmission of genital canine transmissible venereal tumour occurred despite neutered status of the second dog. The aggressive course of disease in both cases, which included metastasis, resistance to therapeutic interventions and ultimate euthanasia of both dogs, is described. The diagnosis of canine transmissible venereal tumour was made using a combination of cytology, histology, immunohistochemistry and PCR to detect the LINE-MYC rearrangement. Practitioners unfamiliar with canine transmissible venereal tumour are reminded of this disease of concern, particularly when imported dogs are placed in multi-dog households, irrespective of neuter status.
Subject(s)
Dog Diseases , Venereal Tumors, Veterinary , Dogs , Animals , Venereal Tumors, Veterinary/diagnosis , Venereal Tumors, Veterinary/drug therapy , Venereal Tumors, Veterinary/pathology , Dog Diseases/diagnosis , Polymerase Chain Reaction/veterinary , Immunohistochemistry , United KingdomABSTRACT
The objective of this multicentre retrospective study was to describe clinical presentation, treatment and outcome and to determine prognostic factors for dogs with presumed primary colorectal lymphoma (PCRL). A total of 31 dogs were included. The predominant features of PCRL were high grade (n = 18) and immunophenotype B (n = 24). Most dogs were substage b (n = 25) with higher prevalence of haematochezia (n = 20). One dog had surgery only. Thirty dogs received chemotherapy; amongst them 13 had surgery or radiotherapy. Progression free survival (PFS) was 1318 days and disease-related median survival time (MST) was 1845 days. Fourteen dogs were alive at the end of the study with a median follow-up time of 684 days (3-4678 days). Younger dogs had longer PFS (P = 0.031) and disease-related MST (P = 0.01). Presence of haematochezia corresponded with longer PFS (P = 0.02). Addition of local treatment to chemotherapy did not significantly improve the outcome (P = 0.584). Canine PCRL has considerably longer PFS and MST than other forms of non-Hodgkin's lymphoma.
Subject(s)
Colorectal Neoplasms/veterinary , Dog Diseases/diagnosis , Lymphoma/veterinary , Age Factors , Animals , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/pathology , Colorectal Neoplasms/therapy , Combined Modality Therapy/veterinary , Dog Diseases/pathology , Dog Diseases/therapy , Dogs , Female , Lymphoma/diagnosis , Lymphoma/pathology , Lymphoma/therapy , Male , Prognosis , Retrospective Studies , Survival AnalysisABSTRACT
Information about histiocytic disease in cats is limited. The aim of this study was to document clinical findings and outcome in feline histiocytic disorders, and characterize the expression of PDGFRß and KIT in order to identify potential treatment targets. Morphologically diagnosed feline histiocytic tumours were reviewed and characterized by immunohistochemistry (IHC). Five cases of feline progressive histiocytosis (FPH), eight histiocytic sarcomas (HS) and two haemophagocytic histiocytic sarcomas (HaeHS) were confirmed. PDGFRß was variably positive in most histiocytic cases, while KIT was negative in all. Clinical presentation, treatment and outcome were also evaluated. Partial responses were recorded in measurable disease with tyrosine kinase inhibitors and lomustine, and radiotherapy achieved long-term control in some cases. Survival times were shortest in HaeHS and disseminated disease. PDGFRß, but not KIT, may represent a therapeutic target in feline histiocytic disorders but more studies are needed to investigate other potential treatment targets.
Subject(s)
Cat Diseases/metabolism , Histiocytic Disorders, Malignant/veterinary , Proto-Oncogene Proteins c-kit/biosynthesis , Receptor, Platelet-Derived Growth Factor beta/biosynthesis , Animals , Biomarkers, Tumor , Cat Diseases/diagnosis , Cat Diseases/pathology , Cats , Databases as Topic , Female , Histiocytic Disorders, Malignant/metabolism , Histiocytic Disorders, Malignant/pathology , Histiocytic Disorders, Malignant/therapy , Immunohistochemistry/veterinary , Male , Neoplasm Staging , Treatment Outcome , United KingdomABSTRACT
An eight-year-old, neutered, male German short-haired pointer was presented for a chronic cough and an intrathoracic mass. Computed tomography revealed a mass with low attenuation in the right caudal lung lobe that invaded the principal bronchi. The mass was removed by right caudal and accessory lung lobectomy. The histopathological diagnosis was pulmonary lipoma. The clinical signs resolved following surgery. There was no evidence of recurrence or de novo lesions on computed tomography performed 12 months post-surgery. To the authors' knowledge, this is the first report of a pulmonary lipoma in a dog.
