ABSTRACT
Reported is the case of a 24-year-old white man with inoperable giant cell carcinoma of the thyroid who achieved tumor regression following therapy with bleomycin, Adriamycin and cisplatinum. After 2 courses of chemotherapy, the tumor was deemed operable, and the patient underwent total thyroidectomy followed by radiation to the neck and upper mediastinum without maintenance chemotherapy. Two-and-one-half years after the initial diagnosis, he developed pulmonary metastases which again responded to Adriamycin and cisplatinum therapy. The above approach suggests that inoperable thyroid carcinoma can be made operable by preoperative combination chemotherapy. This treatment program deserves further exploration for a greater number of patients.
Subject(s)
Antineoplastic Agents/therapeutic use , Carcinoma/drug therapy , Thyroid Neoplasms/drug therapy , Adult , Bleomycin/therapeutic use , Carcinoma/pathology , Carcinoma/surgery , Cisplatin/therapeutic use , Doxorubicin/therapeutic use , Drug Therapy, Combination , Follow-Up Studies , Humans , Male , Thyroid Neoplasms/pathology , Thyroid Neoplasms/surgeryABSTRACT
Human lymphocytes were cultured in vitro with multiple concentrations of antigen, mitogen, and allogeneic cells. The addition of levamisole to stimulated cultures in concentrations of 0.03-33 mug/ml significantly amplified the response of lymphocytes to these stimuli with little or no effect on control cultures. The combination of stimulus and levamisole concentration which produced amplification was unique for each individual culture. The inconsistent results found here and elsewhere may reflect instability of levamisole under conditions of the in vitro lymphocyte culture system.
Subject(s)
Levamisole/pharmacology , Lymphocyte Activation/drug effects , Antigens , Humans , Immunity, Cellular/drug effects , Lectins/pharmacology , Lymphocytes/drug effects , Lymphocytes/immunology , Mitogens/pharmacology , Streptodornase and Streptokinase/pharmacologyABSTRACT
A procedure for administering BCG by scarification that allows for speed of application and standardization of technique was discribed.
