ABSTRACT
The effect of antihistaminic drugs, histamine and their combinations on the development of anaphylactic shock and the period of repeated resolution doses was studied in rabbit experiments. It was established that administration of dimedrol during sensibilization aggravated while diazolin and histamine attenuated the course of anaphylactic shock and periods of repeated resolution injections. Simultaneous administration of antihistaminic agents and histamine enhanced the allergization of the body. Under conditions reported dimedrol prevented hypertrophy of the adrenals that occurred in response to sensibilization. Meanwhile diazolin did not interfere with the reaction development and histamine stimulated it. Combined administration of the antihistaminic agents and histamine provoked an inhibition of the above reaction of the adrenals to body sensibilization.
