ABSTRACT
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 Subject(s)
Acridines/pharmacology
, Antimalarials/pharmacology
, Plasmodium falciparum/drug effects
, Acridines/chemical synthesis
, Acridines/chemistry
, Animals
, Antimalarials/chemical synthesis
, Antimalarials/chemistry
, Molecular Structure
, Parasitic Sensitivity Tests
, Plasmodium falciparum/growth & development
, Stereoisomerism
, Structure-Activity Relationship
