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Chem Commun (Camb) ; 50(62): 8593-6, 2014 Aug 11.
Article in English | MEDLINE | ID: mdl-24956071

ABSTRACT

The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.


Subject(s)
Cycloaddition Reaction/methods , Myeloid Cell Leukemia Sequence 1 Protein/metabolism , Sesquiterpenes/chemical synthesis , bcl-X Protein/metabolism , Models, Molecular , Molecular Docking Simulation , Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors , Sesquiterpenes/pharmacology , bcl-X Protein/antagonists & inhibitors
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