[Is it possible to predict experimentally the anti-inhibitory action of some neuroleptics?]. / L'action désinhibitrice de certains neuroleptiques est-elle prévisible expérimentalement?

Shortening of behavioural despair in mice, test that Porsolt and coll. have proposed for the screening of anti-depressive drugs, is able to reveal thymoanaleptic and/or desinhibitory properties of several neuroleptic-desinhibiting substances such as thioproperazine, carpipramine and sulpiride.

[Effect of isoprenaline, in mice anesthetized with pentobarbital, on the cerebral concentration of barbiturates and on the blood levels of free fatty acids]. / Influence exercée par l'isoprénaline, chez la souris endormie au pentobarbital, sur la concentration cérébrale du barbiturique et sur les taux sanguins d'acides gras libres.

In mice isoprenaline increases duration of pentobarbital narcosis without modification of cerebral levels. A correlation between duration of sleep and FFA seric levels increased by isoprenaline is demonstrated. This dual effect is suppressed by pindolol. These facts suggest that hepatic metabolism of pentobarbital is slowed by lipo-mobilisation.

[Lithium modifications of the cataleptogenic properties of various neuroleptic drugs in the rat]. / Modifications par le lithium des propriétés cataleptigènes de quelques neuroleptiques chez le rat.

After unique ip injection (11,78 mEq/kg) LiCl increases in the Rat catalepsy produced by chlorpromazine, prochlorperazine, fluphenazine, levomepromazine, haloperidol and reserpine. This phenomenon is more important according to cataleptigenic properties of neuroleptic drugs. After repeated injections of LiCl (5 mEq/kg/d/5 dip) potentiation of catalepsy is more fugacious and not produced by levomepromazine and reserpine. LiCl would interfere at enzymatic level with dopaminergic transmission either by inhibiting activity of cerebral adenylcyclase (unique injection) or by inhibiting dopamine synthesis (repeated injections).

[The effect of previous administration of adrenaline or isoprenaline on the activity of several hypnotics in mice]. / Influence de l'administration préalable d'adrénaline ou d'isoprénaline sur l'activité de quelques hypnotiques chez la souris

Previous administration of adrenaline (0.5 mg/kg i.p.) and isoprenaline (10 mg/kg i.p.) enhances activity of several hypnotic drugs (pentobarbital, barbital, chloral hydrate) in mice but is without effect upon hypnotic activity of ethanol. This potentialisation is blocked by previous administration of pindolol, but not by phentolamine. Administration of SKF 525 A demonstrates that metabolism of pentobarbital is modified by this enzymatic inhibitor, which is not the case for other hypnotics.