ABSTRACT
In vitro lymphocytes from healthy donors with crude (HCMV), heat inactivated (HCMVi) and infected human fetal fibroblasts (HCMVFF) were stimulated. In all the experiments peak titers of alfa Interferon (IFN) were present 24 h after exposure to antigens. On the other hand, at least after seven days, only lymphocytes of seropositive donors stimulated by HCMVFF and HCMV showed gamma IFN production. Our HCMVFF gave much higher IFN yields than free virus. Our data suggest that HCMVFF and HCMV are recognised by lymphocytes of HCMV specific memory and HCMVFF give additional and more reproducible information on HCMV specific cellular immunity.
Subject(s)
Antigens, Viral/immunology , Cytomegalovirus/immunology , Interferon Type I/biosynthesis , Interferon-gamma/biosynthesis , Lymphocytes/metabolism , Fibroblasts , Humans , Lymphocytes/immunologyABSTRACT
In this study a sero-epidemiological investigation on 127 renal allograft recipients was examined. In these patients, treated with Cyclosporine A or conventional drugs, antibody response to various antigens (Cytomegalovirus, Herpes simplex, Varicellae/Zoster and Mycoplasma pneumoniae) was examined. The data were compared to the healthy population and dialyzed subjects.
Subject(s)
Kidney Transplantation , Transplantation Immunology , Adolescent , Adult , Antibodies, Viral/analysis , Antibody Formation , Cyclosporins/therapeutic use , Cytomegalovirus/immunology , Female , Herpesvirus 3, Human/immunology , Humans , Male , Middle Aged , Mycoplasma pneumoniae/immunology , Renal Dialysis , Simplexvirus/immunologySubject(s)
Cardiomyopathies/diagnosis , Adult , Angiography , Coronary Vessels , Female , Humans , Male , Middle AgedABSTRACT
The possible iatrogenic effects of some drugs commonly employed in heart cases (digitalis, quinidine, procainamide, antihypertensives, etc.) and the possible risks of electrical stimulation techniques are described. Attention is also given to the dangers associated with erroneous laboratory data, or the mistaken interpretation of correct data by the physician. Some illustrative cases are presented.
Subject(s)
Anti-Arrhythmia Agents/adverse effects , Antihypertensive Agents/adverse effects , Cardiovascular Diseases/drug therapy , Digitalis Glycosides/adverse effects , Drug-Related Side Effects and Adverse Reactions , Arrhythmias, Cardiac/chemically induced , Cardiovascular Diseases/chemically induced , Drug Hypersensitivity , Gastrointestinal Diseases/chemically induced , Heart Block/therapy , Heart Diseases/drug therapy , Hematologic Diseases/chemically induced , Humans , Hypokalemia/chemically induced , Pacemaker, Artificial/adverse effects , Psychoses, Substance-Induced , Respiratory Insufficiency/chemically inducedABSTRACT
The main coronary risk factors were estimated in a series of 287 myocardial infarct patients admitted to a coronary unit. Particular attention is drawn to smoking, arterial hypertesion, diabetes and hypercholesterolaemia in this respect. 24 cases in patients under 40 yr where cigarette smoking was by far the most important factor are examined more closely.
