[The therapeutic effect of glycosaminoglycan polysulfate (Arteparon) in arthroses depending on the mode of administration (intraarticular or intramuscular)]. / Der Therapieeffekt von Glycosaminoglycanpolysulfat (Arteparon) bei Arthrosen in Abhängigkeit von der Applikationsart (intraartikulär oder intramuskulär).

The effect of GAGPS (Arteparon) was investigated on patients with osteoarthritis of hip-joints in dependence from the method of application. By that way 50 patients got each 6 injections with 125 mg/0,5 ml Arteparon intraarticular and 50 patients each 10 injections with 125 mg/0,5 ml Arteparon intramuscular. We have documented the qualities of pain, function and motility of the treated hip-joints. The tests applied have demonstrated that there is no significant difference between the both applications, in both groups the effect was good to the same extent. The therapeutic effect and the further indications by intramuscular administration of the GAGPS are discussed.

[Human joint capsule in osteoarthrosis (morpholocical changes) (author's transl)]. / Morphologische Veränderungen der synovialen Gelenkkapselanteile bei Arthrosis deformans.

Morphological investigations of the joint capsules in osteoarthrotic-changed joints have given rise to doubts about the present theory of the causal aetiology of the osteoarthrosis. In every inspected and demonstrated illustration beside the partly normal capsules segments could be found every transition between mild regressive alterations and most massive proliferative changes of the conective tissue and the lining cell layer. It was extraordinary, that the strongly dilated vessels were filled with red blood cells. In another part of the same case was found a massive stricture caused by concentrically deposited substances, which were impregnated with collagenous fibers. Regeneration of the vessels frequently happened adjacent totally obstructed ones. Round-cell infiltrations, granulocytes or other indications of an inflammatory synovitis are found only in a few cases. The intracartilaginous enzymatic reactions, which have been much talked of and which were explained as characteristic of the osteoarthrosis cannot be the cause of the degradation of the cartilage, particularly, because of the normal cell count which is to be found in the synovial fluid. We can answer this problem, if we can prove that the substrates of the chondral metabolism themselves exert a direct or indirect influence on the interstitial connective tissue with induction of the powerful proliferation of the same tissue. The changes in the transit zone would be secondary and their effect on the lining cell layer would increase the progression of the arthrotic events.