[Cerebrocrast correction of reparative osteogenesis on the background of chronic stress]. / Korektsiia tserebrokrastom reparativnogo osteogenezu na foni khronichnogo stresu.

Protective action of cerebrokrast--a derivative from 1,4-dihydropyridine--on the processes of reparative osteogenesis in rats in case of combined action of chronic emotional-pain stress and trauma of mandibular was determined. It is stipulated by a antioxidant properties of cerebrokrast, as well as its stabilizing influence on glycoproteins and calcium homeostasis. The redeived data extend the idea about general-metabolic action of the investigated nootrop at the level of the whole organism and testify worthwhile of its use for prophylaxis of extreme conditions.

[The effect of mexidol on thymus cells in chronic hypokinesia]. / Vplyv meksydolu na klityny tymusa pry khronichnii hipokineziï.

The dynamic of mexidol's (3-oxipyridine derivate) influence on rats' thymic cells was studied under the conditions of 30-days hypokinesia. It was shown, that changes of thymic cells' content under the chronic hypokinesia developed in some stages. The prevent administration of mexidol (100 mg/kg of body weight) modified the lymphoid cells' migration. The remedy's effects on quantitative parameters of thymic cell's populations depended on stress stage and were synergic to natural adaptive processes. The most expressed mexidol's normalizing effect on thymic cells was marked on the 30th day of hypokinesia.

[The hordox correction of excessive proteolytic activity and the sialic acid content of the blood under an emotional influence on rabbits]. / Korektsiia hordoksom nadmirnoï aktyvnosti proteolizu ta vmistu sialovykh kyslot v krovi pid chas emotsiinoho vplyvu na kroliv.

The influence of the acute emotional stress on the activity of proteolysis and content of free sialic acids in the blood under usual conditions and after the preliminary introduction of gordox has been studied in the experiment on rabbits. It is established that the parallel rise of their levels under stress reflects degradation of glycoproteins and fragments containing sialic acids under the influence of the increased activity of proteinases. Gordox, together with the inhibition of excessive activation of proteolysis, prevents the rise of the level of sialic acids under the influence of the stress action. The conclusion is made that it is expedient to use inhibitors of proteolytic enzymes for prevention of cellular lesions in stress.