The impact of social rhythm and sleep disruptions on waist circumference after job loss: A prospective 18-month study.

OBJECTIVE: This study prospectively examined change in waist circumference (WC) as a function of daily social rhythms and sleep in the aftermath of involuntary job loss. It was hypothesized that disrupted social rhythms and fragmented/short sleep after job loss would independently predict gains in WC over 18 months and that resiliency to WC gain would be conferred by the converse. METHODS: Eligible participants (n = 191) completed six visits that included standardized measurements of WC. At the baseline visit, participants completed the social rhythm metric and daily sleep diary and wore an actigraph on their nondominant wrist each day for a period of 2 weeks. RESULTS: When controlling for obesity and other covariates, WC trajectories decreased for individuals with more consistent social rhythms, more activities in their sdiocial rhythms, and higher sleep quality after job loss. WC trajectories did not change for individuals with lower scores on these indicators. CONCLUSIONS: The frequency and consistency of social rhythms after job loss play a key role in WC loss. These findings support the implementation of social rhythm interventions after job loss, a potentially sensitive time for the establishment of new daily routines that have an impact on metabolic health.

Evaluation of call volume and negative emotions in emergency response system telecommunicators: a prospective, intensive longitudinal investigation.

Emergency telecommunicators are essential first responders tasked with coordinated communication within the emergency response system (ERS). Despite their exposure to significant job demands, little is known about the effect of call load or call type on emotional state within these workers. Therefore, we employed a prospective, intensive longitudinal design to examine whether emergency-eligible call volume would lead to higher intensity negative emotions post-shift when controlling for pre-shift negative emotions and a number of other work and individual factors, including work duration and night shift. A total of 47 ERS telecommunicators (dispatchers, operators, other) completed ratings over working shifts within a two-week period. Call frequency was gathered through the agency Computer-Assisted Dispatch database. Negative emotions of irritation, stress, worry, and fatigue were measured through the Visual Analogue Scale administered before and after shift. Mixed linear modeling demonstrated that telecommunicators who received more calls per hour (Estimate = 3.56, SE = 1.44, p < 0.05) and more-than-usual calls per hour (Estimate = 1.97, SE = .94, p < 0.05) had higher levels of post-shift irritability. Longer-than-usual working hours also predicted higher levels of post-shift irritability (Estimate = 1.32, SE = 0.59, p < 0.05). Call volume did not predict other negative emotions, although secondary analyses demonstrated that a larger number of chronic calls lead to greater levels of post-shift worry. ERS telecommunication agencies aiming to reduce negative emotions in workers may benefit from implementing policies and programs that target working hours, call load, and work-life balance.

Maternal Bonding Predicts Actigraphy-Measured Sleep Parameters in Depressed and Nondepressed Adults.

Associations between subjective maternal bonding recalled from the first 16 years of life and current sleep indices were investigated in a clinical sample of 34 adults with major depressive disorder and 36 normal controls (n = 70) using the self-report parental bonding instrument and wrist actigraphy. Results of multiple linear regression analyses indicated that reports of maternal bonding indices were associated with several sleep indices in adulthood independent of depression status. Higher levels of maternal care were associated with greater time in bed and total sleep time. Higher levels of maternal overprotection were associated with fewer awakenings. Findings indicate that reported maternal bonding characteristics in childhood are related to objectively measured sleep characteristics in adulthood, independent of mood state.

Using Web-Based Surveys to Explore Equine Industry Practices and Future Research Needs.

Social media are an ever-present part of daily life and for researchers and may be a useful platform to increase potential participant pools for Web-based surveys. Although survey usage to evaluate practices in the equine community is not new, the use of social media to advertise and enhance the usage of Web-based surveys is novel. In 2018, the University of Minnesota (UMN) equine Extension program developed and administered two Web-based surveys through the UMN equine Extension Facebook page and monthly e-newsletter. Surveys focused on industry practices and motivating factors behind the usage of hay nets and methods to provide water in the winter to horses. Two thousand eighty-eight participants started the hay net survey with a completion rate of 96%, whereas the winter water survey had a completion rate of 94%, with 930 participants starting the survey. Participant demographics aligned with previous survey populations and represented all regions of the United States. Both surveys revealed information, which described current industry practices as well as future research needs. In addition, participants were asked if scientific research would impact future decision-making in regards to equine management. When exploring hay net practices, most participants responded "maybe" (48%, n = 527), whereas for the winter water survey, the majority responded "yes" (68%, n = 877). Web-based surveys administered through social media present multiple benefits, including savings of both cost and labor, compared with traditional mailed surveys. Despite the success observed with the present surveys, this methodology may not be suitable for organizations with limited social media followers.

The Effect of Goldfish (Carassius auratus) on Water Quality in Horse Stock Tanks.

Goldfish (Carassius auratus) have been reported as a method to keep water tanks clean; however, little information exists on this approach. The objectives were to evaluate the efficacy of goldfish on maintaining water quality in tanks and to evaluate the frequency that this method is used. The first objective was completed during June through October 2017 in St. Paul, MN, using plastic and metal 379 L stock tanks, each with and without goldfish in a drylot that housed six adult horses. The stocking rate was 5 goldfish per tank. Daily readings of total dissolved solids (TDS) and water turbidity (NTU), and weekly samples to measure chlorophyll a were taken. At the end of each 28-day period, tanks were cleaned and rotated. Plastic tanks had lower TDS than metal tanks (P < .001); however, metal tanks had lower NTU and chlorophyll a (P ≤ .008). Adding goldfish resulted in lower TDS (P < .001); however, there was no effect on NTU or chlorophyll a (P ≥ .097). No parameters had an impact on horse preference (P ≥ .108). The second objective was completed using an online survey that was open from October 31 until December 15, 2018. Of the 672 completed surveys, 56% had not tried using goldfish in water tanks, 26% had utilized goldfish in the past, and 18% currently used goldfish. The inclusion of goldfish in water tanks did not affect all water quality parameters; however, 44% of survey respondents had tried, or were currently using, this management method.

Estimation of Actual and Ideal Bodyweight Using Morphometric Measurements of Miniature, Saddle-Type, and Thoroughbred Horses.

Adding breed type, height, and neck circumference to body length and girth circumference improves bodyweight (BW) estimation in different breeds of horses; however, equations have not been developed for all breed types. The objectives were to develop BW estimation equations for Miniature, saddle-type, and Thoroughbred horses using morphometric measurements. Measurements were collected on adult (≥3 years, nonpregnant) saddle-type (n = 209), adult (n = 249) and juvenile (<3 years, n = 61) Miniatures, and adult Thoroughbreds (n = 100). Personnel determined body condition score (BCS), measured withers height and girth circumference at the third thoracic vertebra, body length from the point of the shoulder to the point of the buttock and to a line perpendicular to the point of the buttock, and neck circumference at the midway point between the poll and withers. Each horse was weighed using a livestock scale. Bodyweight estimations equations were developed using linear regression modeling and log transformation. Mean (±standard deviation) BCS was 6.1 (±0.8), 5.4 (±0.6), 6.0 (±1.0), and 5.0 (±0.6) for adult and juvenile Miniatures, saddle-type, and Thoroughbreds, respectively. Bodyweight estimation equations developed through the current research were within 4% of the scale BW and offered improvements over previous BW estimation equations and weight tapes, which were off by 5%-25%. Owner-estimated BW was within 8%-15% of scale BW. Morphometric measurements were successfully used to develop BW equations for Miniature, saddle-type, and Thoroughbred horses. The equations will assist owners and professionals with managing horse BW and will be added to the Healthy Horse application.

A Randomized Study Comparing the Incidence of Postoperative Pain After Phrenic Nerve Infiltration Vs Nonphrenic Nerve Infiltration During Thoracotomy.

Thoracotomy is a common surgical procedure performed worldwide for lung disease. Despite major advances in analgesia, patients still experience severe shoulder, central back and surgical incision site pain in the postoperative period. This study aimed to assess whether intraoperative phrenic nerve infiltration reduces the incidence of postoperative pain and improves peak flow volume measurements during incentive spirometry. 90 patients undergoing open lobectomy were randomly assigned to have phrenic nerve infiltration (n = 46) or not (n = 44). The phrenic nerve infiltration group received 10 mL of 0.25% bupivacaine into the periphrenic fat pad. Preoperative assessments of spirometry and pain scores were recorded (at rest and with movement). Postoperative assessments included peak flow and pain measurements at intervals up to 72 hours. Less shoulder pain was experienced with phrenic nerve infiltration up to 6 hours postsurgery at rest (P = 0.005) and up to 12 hours with movement (P < 0.001). Reduced back pain was reported in the phrenic nerve infiltration group up to 6 hours after surgery both at rest (P = 0.001) and with movement (P = 0.00). Phrenic nerve infiltration reduced pain at the incision site for up to 3 hours both at rest (P < 0.001) and with movement (P = 0.001). Spirometry readings dropped in both groups with consistently lower readings at baseline and follow-up in the PNI group (P = 0.007). Lower analgesic usage of patient controlled analgesia morphine (P < 0.0001), epipleural bupivacaine (P = 0.001), and oramorph/zomorph (P = 0.0002) were recorded. Our findings indicate that the use of phrenic nerve infiltration significantly reduced patient pain scores during the early postoperative period, particularly during movement. We believe that each technique has advantages and disadvantages; however, further studies with large sample size are warranted.

Sonic Hedgehog Signaling Regulates Hematopoietic Stem/Progenitor Cell Activation during the Granulopoietic Response to Systemic Bacterial Infection.

Activation and reprogramming of hematopoietic stem/progenitor cells play a critical role in the granulopoietic response to bacterial infection. Our current study determined the significance of Sonic hedgehog (SHH) signaling in the regulation of hematopoietic precursor cell activity during the host defense response to systemic bacterial infection. Bacteremia was induced in male Balb/c mice via intravenous injection (i.v.) of Escherichia coli (5 × 107 CFUs/mouse). Control mice received i.v. saline. SHH protein level in bone marrow cell (BMC) lysates was markedly increased at both 24 and 48 h of bacteremia. By contrast, the amount of soluble SHH ligand in marrow elutes was significantly reduced. These contrasting alterations suggested that SHH ligand release from BMCs was reduced and/or binding of soluble SHH ligand to BMCs was enhanced. At both 12 and 24 h of bacteremia, SHH mRNA expression by BMCs was significantly upregulated. This upregulation of SHH mRNA expression was followed by a marked increase in SHH protein expression in BMCs. Activation of the ERK1/2-SP1 pathway was involved in mediating the upregulation of SHH gene expression. The major cell type showing the enhancement of SHH expression in the bone marrow was lineage positive cells. Gli1 positioned downstream of the SHH receptor activation serves as a key component of the hedgehog (HH) pathway. Primitive hematopoietic precursor cells exhibited the highest level of baseline Gli1 expression, suggesting that they were active cells responding to SHH ligand stimulation. Along with the increased expression of SHH in the bone marrow, expression of Gli1 by marrow cells was significantly upregulated at both mRNA and protein levels following bacteremia. This enhancement of Gli1 expression was correlated with activation of hematopoietic stem/progenitor cell proliferation. Mice with Gli1 gene deletion showed attenuation in activation of marrow hematopoietic stem/progenitor cell proliferation and inhibition of increase in blood granulocytes following bacteremia. Our results indicate that SHH signaling is critically important in the regulation of hematopoietic stem/progenitor cell activation and reprogramming during the granulopoietic response to serious bacterial infection.

Longitudinal assessment of daily activity patterns on weight change after involuntary job loss: the ADAPT study protocol.

BACKGROUND: The World Health Organization has identified obesity as one of the most visible and neglected public health problems worldwide. Meta-analytic studies suggest that insufficient sleep increases the risk of developing obesity and related serious medical conditions. Unfortunately, the nationwide average sleep duration has steadily declined over the last two decades with 25% of U.S. adults reporting insufficient sleep. Stress is also an important indirect factor in obesity, and chronic stress and laboratory-induced stress negatively impact sleep. Despite what we know from basic sciences about (a) stress and sleep and (b) sleep and obesity, we know very little about how these factors actually manifest in a natural environment. The Assessing Daily Activity Patterns Through Occupational Transitions (ADAPT) study tests whether sleep disruption plays a key role in the development of obesity for individuals exposed to involuntary job loss, a life event that is often stressful and disrupting to an individual's daily routine. METHODS: This is an 18-month closed, cohort research design examining social rhythms, sleep, dietary intake, energy expenditure, waist circumference, and weight gain over 18 months in individuals who have sustained involuntary job loss. Approximately 332 participants who lost their job within the last 3 months are recruited from flyers within the Arizona Department of Economic Security (AZDES) Unemployment Insurance Administration application packets and other related postings. Multivariate growth curve modeling will be used to investigate the temporal precedence of changes in social rhythms, sleep, and weight gain. DISCUSSION: It is hypothesized that: (1) unemployed individuals with less consistent social rhythms and worse sleep will have steeper weight gain trajectories over 18 months than unemployed individuals with stable social rhythms and better sleep; (2) disrupted sleep will mediate the relationship between social rhythm disruption and weight gain; and (3) reemployment will be associated with a reversal in the negative trajectories outlined above. Positive findings will provide support for the development of obesity prevention campaigns targeting sleep and social rhythms in an accessible subgroup of vulnerable individuals.