ABSTRACT
We have studied the effect of ultracaine DS forte on local blood flow of the rat gum as well as on the development of the convulsion activity of the brain at systemic injection. Experiments were carried out on 12 mongrel albino mail rats of 200-250 g weight. In the I group of animals under the light chloral hydrate anesthesia we studied the changes of local blood flow in the rat gum of lower jaw after ultracaine DS forte injection (right side) and the similar quantity of phisiological solution (left side). According to our data, in the right gum, the rate of local blood flow decreases statistically significantly at 18%, while the injection of physiological solution did not result in any changes. In the II group, experiments were carried out on the animals with bipolar electrodes in neocortex, as well as in the right and the left dorsal hippocampus. On the fifth day after surgical intervention, on the background of registration of electric activity of the above stated structures 0,03-0,04 ml of ultracaine Ds forte was injected intraperitoneally, which did not result in any significant deviation on the encephalogram. 10-fold doze injection was followed by abortion of epileptic discharges (0,3 ml), but repeated injection of 0,3 ml of preparation resulted in generalized clone-tonus type seizure activity. Simultaneously, clone-tonus type behavioral manifestation was revealed.
Subject(s)
Blood Flow Velocity/drug effects , Brain/physiopathology , Carticaine/pharmacology , Cerebral Cortex/physiopathology , Gingiva/blood supply , Hippocampus/physiopathology , Seizures/drug therapy , Anesthetics, Local/pharmacology , Animals , Brain/drug effects , Cerebral Cortex/drug effects , Disease Models, Animal , Electrodes, Implanted , Electrophysiology/methods , Follow-Up Studies , Gingiva/drug effects , Hippocampus/drug effects , Male , Rats , Seizures/physiopathologyABSTRACT
According to the data of direct electroencephalography (EEG) human fetus can develop circadian rhythm of sleep-wake cycle before birth. Healthy fetus during birth is awake and takes an active part in the delivery. The fetus sleep during birth is developed only in hypoxic states. EEG irregularities of sleep are noticed yet in fetal stage. Children aged 0-1 year develop five phases of sleep: drowsiness, active sleep, sleep of middle depth, deep sleep, paradoxical REM sleep. Maturity of superficial sleep terminates by the 10th-12th month of life. The sleep of average depth and deep sleep terminate maturity by the 2nd month of life. Duration of paradoxical sleep increases considerably by the age 12th month and is divided into 2 stages. By the age of 12 months paradoxical sleep remains immature. In children of the same age with CNS disorder the structural composition of sleep changes: active sleep is prolonged, sleep of middle depth is not changed, deep sleep does not develop, paradoxical-REM sleep is atypical.
