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Phenotype of BTK-lacking myeloid cells during prolonged COVID-19 and upon convalescent plasma.
Gomes, André M C; Farias, Guilherme B; Trombetta, Amelia C; Godinho-Santos, Ana; Parreira, Inês; Gonçalves, Hélder Diogo; Simões, Mariana Lessa; Aguiar, Patrício; Deveza, Maria Manuel; Inácio, João; Sousa, Ana E; da Silva, Susana Lopes.
Eur J Haematol ; 110(2): 209-212, 2023 Feb.
Article in English | MEDLINE | ID: mdl-36208028

ABSTRACT

XLA patient with 7-month course of COVID-19 with persistent plasma SARS-CoV-2 load revealed a sustained non-inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS-COV-2 infection.


Subject(s)
COVID-19 , Genetic Diseases, X-Linked , Humans , Protein-Tyrosine Kinases , Agammaglobulinaemia Tyrosine Kinase/genetics , SARS-CoV-2 , COVID-19 Serotherapy , Myeloid Cells , Phenotype
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