ABSTRACT
The word deals with the results obtained in the study of the reactogenicity and immunological activity of concentrated and inactivated tissue-culture tick-borne encephalitis vaccine, manufactured by the Chumakov Institute of Poliomyelitis and Viral Encephalitides, in the immunization of children and adolescents. The vaccine proved to be moderately reactogenic and exhibited pronounced immunological activity. In 91.5% of the immunized children the fourfold increase of the antibody level was observed. On the basis of the data obtained in this study the tick-borne encephalitis vaccine was recommended for use in medical practice for the prophylaxis of tick-borne encephalitis among children and adolescents.
Subject(s)
Encephalitis Viruses, Tick-Borne/immunology , Encephalitis, Tick-Borne/prevention & control , Immunization/methods , Viral Vaccines/immunology , Adolescent , Analysis of Variance , Antibodies, Viral/blood , Austria , Child , Humans , Immunization/statistics & numerical data , Immunization, Secondary/methods , Immunization, Secondary/statistics & numerical data , Russia , Time Factors , Vaccines, Inactivated/adverse effects , Vaccines, Inactivated/immunology , Viral Vaccines/adverse effectsABSTRACT
The results of the introduction of the system of epidemiological surveillance on vaccinal prophylaxis on the territory of Perm Province are presented. This system has permitted the realization of the principles of the regional tactics of immunization, while following the unified strategy acting on the territory of the Russian Federation. The optimization of the organizational foundations of vaccinal prophylaxis has made it possible to maintain the morbidity rates if infections, controlled by means of specific prophylaxis, on the levels below the average figures for the Federation and to preserve more stable tendencies to their decrease.