1.
FEMS Microbiol Lett
; 201(2): 243-7, 2001 Jul 24.
Article
in English
| MEDLINE
| ID: mdl-11470368
ABSTRACT
The chloride channel antagonists anthracene-9-carboxylic acid, ethacrynic acid and niflumic acid were found to be fungistatic and morphogenic when tested against the ascomycete Neurospora crassa. Potency increased with decreasing pH, suggesting that the protonated forms of the compounds were active. Niflumic acid produced the most pronounced growth aberrations which may reflect an ability to acidify the cytoplasm and block the plasma membrane anion channel of N. crassa.