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Mycopathologia ; 153(1): 25-8, 2002.
Article in English | MEDLINE | ID: mdl-11913762

ABSTRACT

The non-steroidal anti-inflammatory drug niflumic acid was found to inhibit growth of the yeast form of Candida albicans. Niflumic acid inhibited respiratory oxygen uptake and it is hypothesised that this was achieved by cytosolic acidification and block of glycolysis. Inhibitory concentrations are compatible with current practice of topical application.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Antifungal Agents/pharmacology , Candida albicans/drug effects , Niflumic Acid/pharmacology , Candida albicans/growth & development , Candida albicans/metabolism , Culture Media , Oxygen Consumption/drug effects
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