A comparative assessment of consolidation materials applied to burned bone.

Fire-altered or fragmentary bone presents a challenge to forensic anthropologists and bioarchaeologists due to its characteristic friability. A potential solution to this problem is the use of consolidant materials on fragile osteological material, including burned remains. Although anthropologists and odontologists employ a variety of consolidant materials, there is no consensus regarding which material is most appropriate. Four easily obtained and commonly used consolidants, Acryloid™ B-72, Acrysol™ WS-24, Rhoplex™ B-60A, and Butvar® B-98, were compared to assess ease of material application and ability to stabilize burned bone. Each consolidant was applied to a subgroup of the study population at a 10% concentration. Total dry time per specimen, ease of solution preparation and application, and any alteration to the bone's appearance were recorded to assess the practical use of each material in field recovery settings. Nanoindentation, drop weight impact, and forced vibration tests were then performed to assess degree of stabilization. These tests were chosen to mimic possible real-world scenarios where burned bone may undergo damage during and after recovery, including repeated handling and transportation from the fire scene to the lab. Based on both qualitative and quantitative data collected, Acryloid™ B-72 is the most suitable consolidant tested to stabilize burned or fragmentary bone during recovery efforts. If the dry time for Rhoplex™ B-60A could be reduced by using a different solvent, such as acetone, Rhoplex™ B-60A would also be appropriate. Highly calcined areas, and targeted structures that could be utilized for positive identification, including teeth and the frontal sinus, should preferentially be consolidated with Acryloid™ B-72 in the field prior to recovery.

Hepatitis B in the non-residential mentally handicapped population.

This study describes seroprevalence and risk factors for hepatitis B in seven centres caring for non-residential mentally handicapped individuals. Overall, 11% were hepatitis B marker seropositive and 4% had the hepatitis B surface antigen (HBsAg). Male sex and increasing age were associated with seropositive status, and Down's syndrome was associated with the presence of HBsAg. Immediate family members of those with hepatitis B markers were screened and 22% had evidence of hepatitis B markers. Forty-one family members were identified when the mentally handicapped individual was HBsAg positive and of these 13 (32%) were seropositive. This study demonstrates that hepatitis B is a problem for the non-residential mentally handicapped population and confirms the risk of infection to their immediate families.

Prevalence and risk factors for childhood nocturnal enuresis.

A large population based study was carried out to describe the epidemiology of nocturnal enuresis and to outline medical management of the problem. Parents of 1,806 schoolchildren were surveyed and prevalence was ascertained at 13% with two thirds classified as primary enuretics. Significant associated factors included social class, unemployment, family stress and a parental family history of enuresis. Enuretics were more likely to be behind at school, have behavioural problems, soiling and daytime wetting. Enuresis was distressful for the family yet most children never saw a doctor about the problem. In those that did, less than two thirds had a urine test and 40% of parents remained dissatisfied with the outcome of the visit to the doctor. Children were more likely to be prescribed medicine than other treatments whereas the enuresis alarm was recommended for only one in ten children. These findings illustrate that nocturnal enuresis continues to be a problem, that the characteristics of Irish enuretics differ from those in other countries and that medical management of enuresis has room for improvement.

Predicting treatment outcome in nocturnal enuresis.

A presenting sample of 127 consecutive referrals to a community based enuresis clinic were evaluated after treatment with baseline behavioural recording and the enuresis alarm. Almost one in five became dry after baseline recording only while 81 of 96 (84%) enuretics who used the alarm achieved the initial dryness criterion. Successful outcome was associated with the absence of adverse environmental factors and psychiatric disorders in the child. A logistic regression procedure enabled a risk score to be created so that successful outcome could be predicted. Psychiatric disorder in the child, family stress, and the degree of concern shown by the child emerged as the most important prognostic factors in the treatment of enuresis. The favourable success rates with baseline recording and the enuresis alarm confirm the role of conditioning treatment at the forefront of management of enuresis and the risk score allows outcome to be predicted for the first time.

Neurosecretion of arginine vasopressin by an olfactory neuroblastoma causing reversible syndrome of antidiuresis.

A 26-year-old woman with the syndrome of inappropriate antidiuresis demonstrated complete recovery following the resection of an olfactory neuroblastoma. Tissue arginine vasopressin levels by radioimmunoassay, immunohistochemical staining of the tissue arginine vasopressin, postoperative normalization of plasma arginine vasopressin levels, and the clinical resolution are evidence in support of a neurally derived tumor being the direct source of neurosecretion of arginine vasopressin rather than neurohypophyseal secretion or secretion from non-neural tissues, as reported to date in the etiology of the syndrome of inappropriate antidiuresis.