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1.
Protein-binding polyhedral boranes.
Sneath, R L; Wright, J E; Soloway, A H; O'Keefe, S M; Dey, A S; Smolnycki, W D.
J Med Chem ; 19(11): 1290-4, 1976 Nov.
Article in English | MEDLINE | ID: mdl-63551

ABSTRACT

A series of polyhedral borane derivatives containing protein-binding functional groups has been synthesized. Problems encountered in earlier studies (low incorporation levels, gross precipitation of conjugates) have been overcome by including a water-solubilizing gluconamide group in the structure. This modification has allowed high levels of boron to be covalently bound to HGG, forming a completely water-soluble conjugate.


Subject(s)
Boranes/chemical synthesis , Proteins/metabolism , Boranes/metabolism , Humans , In Vitro Techniques , Protein Binding , Structure-Activity Relationship , gamma-Globulins/metabolism
2.
Protein-binding polyhedral boranes II: DL-S-(10-dimethylsulfidooctahydrodecaborane)methionine.
Jacobs, P M; Sneath, R L; Soloway, A H; Dey, A S.
J Pharm Sci ; 65(4): 604-6, 1976 Apr.
Article in English | MEDLINE | ID: mdl-1271267

ABSTRACT

An analog of methionine, DL-S-(10-dimethylsulfidooctahydrodecaborane)methionine, was synthesized from fully protected homoserine. A protected dipeptide with glycine is described.


Subject(s)
Boranes/metabolism , Methionine/analogs & derivatives , Peptides/metabolism , Boranes/chemical synthesis , Chemical Phenomena , Chemistry , Homoserine , Protein Binding
3.
Synthesis and antimalarial evaluation of 9,10-dihydrophenanthrene amino alcohols.
Dey, A S; Neumeyer, J L.
J Med Chem ; 17(10): 1095-100, 1974 Oct.
Article in English | MEDLINE | ID: mdl-4608227

Subject(s)
Phenanthrenes/chemical synthesis , Alcohols/chemical synthesis , Alcohols/therapeutic use , Amines/chemical synthesis , Amines/therapeutic use , Animals , Chickens , Malaria/drug therapy , Mice , Phenanthrenes/therapeutic use , Plasmodium berghei , Structure-Activity Relationship
4.
Protein-binding polyhedral boranes. 1.
Sneath, R L; Soloway, A H; Dey, A S.
J Med Chem ; 17(8): 796-9, 1974 Aug.
Article in English | MEDLINE | ID: mdl-4136020

Subject(s)
Boranes/chemical synthesis , Animals , Antibodies, Neoplasm/metabolism , Boranes/blood , Cattle , Humans , Protein Binding , Serum Albumin, Bovine/metabolism , Solubility , Structure-Activity Relationship , gamma-Globulins/metabolism
5.
Synthesis of diethyl N-dodecylphosphoramidate analogs as potential inhibitors of dental plaque.
Warner, V D; Mirth, D B; Dey, A S.
J Med Chem ; 16(10): 1185-6, 1973 Oct.
Article in English | MEDLINE | ID: mdl-4749476

Subject(s)
Dental Plaque/prevention & control , Organophosphorus Compounds/chemical synthesis , Alkanes/chemical synthesis , Alkanes/pharmacology , Alkanes/therapeutic use , Amides/chemical synthesis , Amides/pharmacology , Amides/therapeutic use , Anti-Infective Agents, Local/pharmacology , Anti-Infective Agents, Local/therapeutic use , Biguanides/pharmacology , Biguanides/therapeutic use , Chlorobenzenes/pharmacology , Chlorobenzenes/therapeutic use , Humans , In Vitro Techniques , Organophosphorus Compounds/pharmacology , Organophosphorus Compounds/therapeutic use , Streptococcus/drug effects , Structure-Activity Relationship
6.
Direction of cyclization of 1,2-bis-(cyanomethyl)benzenes.
Dey, A S; Rosowsky, A; Modest, E J.
J Org Chem ; 35(2): 536-9, 1970 Feb.
Article in English | MEDLINE | ID: mdl-5412143

Subject(s)
Benzene Derivatives , Chemical Phenomena , Chemistry , Cyanides , Oxidation-Reduction
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