ABSTRACT
Neurologic complications of SARS-CoV-2 infection have been reported commonly. Peripheric facial nerve palsy is one of the most reported neurologic problems. However, idiopathic bilateral facial palsy is a very rare complication of SARS-CoV-2 infection. Herein, we present a case of a COVID-19 35-year-old man, which developed bilateral facial palsy.
ABSTRACT
During the COVID-19 pandemic, we had a 25 years old male case without any underlying disease or history of autoimmune disease in COVID-19 Clinic, Isfahan, Iran. He presented with arthralgia and weakness so we started COVID-19 therapeutic regimen. In his hospitalization, creatinine increases and abnormalities in random urine sediment was seen. Methylprednisolone and cyclophosphamide were prescribed due to suspected glomerulonephritis. After renal biopsy the diagnose was confirmed as crescentic proliferative glomerulonephritis. The patient also, underwent plasmapheresis and intravenous immunoglobulin injection. He was discharged healthy without development of new pulmonary symptoms despite immunosuppressive treatment.
Subject(s)
Coronavirus Infections/complications , Glomerulonephritis/complications , Glomerulonephritis/diagnosis , Pneumonia, Viral/complications , Administration, Intravenous , Adult , Biopsy , COVID-19 , Coronavirus Infections/diagnosis , Cyclophosphamide/therapeutic use , Glomerulonephritis/drug therapy , Glomerulonephritis/surgery , Humans , Immunoglobulins/administration & dosage , Male , Methylprednisolone/therapeutic use , Pandemics , Pneumonia, Viral/diagnosis , Treatment OutcomeABSTRACT
This systematic review and meta-analysis were performed to evaluate the effect of omega-3 supplementation on serum levels of inflammatory biomarkers (C-reactive protein [CRP], high-sensitivity CRP [hs-CRP], tumor necrosis factor-alpha, interleukin-6) and albumin in patients on hemodialysis. A literature search was performed in MEDLINE, Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Web of Science, and Google Scholar. Randomized controlled trials that evaluated the effect of omega-3 supplementation versus placebo were selected. Eight randomized controlled trials comprising 371 patients on hemodialysis were included. According to our results, omega-3 supplementation significantly decreased serum levels of CRP (standardized mean difference [SMD]: -1.95 mg/Dl; 95% confidence interval [CI]: -3.09, -0.80) and hs-CRP (SMD: -2.09; 95% CI: -3.62, -0.56) but did not significantly improve albumin (SMD: 0.91; 95% CI: -0.78, 2.59), tumor necrosis factor-alpha (SMD: -1.51; 95% CI: -3.24, 0.22), and interleukin-6 (SMD: 0.72, 95% CI: -0.56, 1.99). We concluded that omega-3 supplementation leads to a significant decrease in serum levels of CRP and hs-CRP.
