ABSTRACT
BACKGROUND: Cohorts of severely ill patients with COVID-19 have been described in several countries around the globe, but to date there have been few published reports from the United Kingdom (UK). Understanding the characteristics of the affected population admitted to intensive care units (ICUs) in the UK is crucial to inform clinical decision making, research and planning for future waves of infection. METHODS: We conducted a prospective observational cohort study of all patients with COVID-19 admitted to a large UK ICU from March to May 2020 with follow-up to June 2020. Data were collected from health records using a standardised template. We used multivariable logistic regression to analyse the factors associated with ICU survival. RESULTS: Of the 156 patients included, 112 (72%) were male, 89 (57%) were overweight or obese, 68 (44%) were from ethnic minorities, and 89 (57%) were aged over 60 years of age. 136 (87%) received mechanical ventilation, 77 (57% of those intubated) were placed in the prone position and 95 (70% of those intubated) received neuromuscular blockade. 154 (99%) patients required cardiovascular support and 44 (28%) required renal replacement therapy. Of the 130 patients with completed ICU episodes, 38 (29%) died and 92 (71%) were discharged alive from ICU. In multivariable models, age (OR 1.13 [95% CI 1.07-1.21]), obesity (OR 3.06 [95% CI 1.16-8.74]), lowest P/F ratio on the first day of admission (OR 0.82 [95% CI 0.67-0.98]) and PaCO2 (OR 1.52 [95% CI 1.01-2.39]) were independently associated with ICU death. CONCLUSIONS: Age, obesity and severity of respiratory failure were key determinants of survival in this cohort. Multiorgan failure was prevalent. These findings are important for guiding future research and should be taken into consideration during future healthcare planning in the UK.
Subject(s)
COVID-19/epidemiology , Critical Illness/epidemiology , Multiple Organ Failure/epidemiology , Obesity/epidemiology , Adult , Aged , COVID-19/complications , COVID-19/therapy , COVID-19/virology , Cohort Studies , Female , Hospital Mortality , Humans , Intensive Care Units , London/epidemiology , Male , Middle Aged , Multiple Organ Failure/complications , Multiple Organ Failure/virology , Obesity/complications , Obesity/therapy , Obesity/virology , Patient Discharge , Prospective Studies , Respiration, Artificial , SARS-CoV-2/pathogenicity , Severity of Illness Index , Treatment Outcome , United Kingdom/epidemiologyABSTRACT
Methaemoglobinaemia is an extremely rare condition with multiple causes, both genetic and acquired. We present a severe case of methaemoglobinaemia occurring in a Brazilian hairdresser working in the UK. She presented after several days of preparing popular 'Brazilian blowdry' treatments for customers at a hair salon. She had been exposed to multiple volatile chemicals, including formaldehyde, without any respiratory protection, and we postulate that this may have caused her illness. If so, this would be the first published case of methaemoglobinaemia caused by exposure to the volatile components of beauty products.
Subject(s)
Air Pollutants, Occupational/adverse effects , Hair Preparations/adverse effects , Methemoglobinemia/chemically induced , Methemoglobinemia/drug therapy , Methylene Blue/therapeutic use , Occupational Exposure/adverse effects , Enzyme Inhibitors/therapeutic use , Female , Humans , Middle AgedSubject(s)
Heart Arrest/therapy , Post-Cardiac Arrest Syndrome/prevention & control , Anticonvulsants/therapeutic use , Cardiopulmonary Resuscitation , Humans , Hyperglycemia/drug therapy , Hypnotics and Sedatives/therapeutic use , Hypoglycemic Agents/therapeutic use , Hypothermia, Induced , Post-Cardiac Arrest Syndrome/therapy , Prognosis , Respiration, Artificial , Seizures/drug therapyABSTRACT
BACKGROUND: Heart positioning during beating heart surgery produces significant haemodynamic compromise either when a deep pericardial stitch (DPS) or apical suction devices (ApSDs) are used. In this study the two techniques' haemodynamic performance and effect on intracardiac structures were compared through transoesophageal echocardiography (TEE) obtained volume measurements and three-dimensional ventricular and mitral valve computer reconstructions. METHODS: Sequential 0 degrees to 180 degrees TEE images of the left heart were obtained in 10 patients undergoing beating heart surgery. Measurements with both techniques in three different positions were obtained: at baseline, the heart elevated to access its inferior surface and the heart elevated and rotated to access its lateral surface. Three-dimensional computer reconstructions of the mitral valve and the left heart were generated. Ventricular volume measurements were used to calculate stroke volume, ejection fraction and differences from baseline. An analysis of variance between each technique in all three positions was performed. RESULTS: Central venous, left atrial and pulmonary artery pressures were significantly increased with either technique during positioning. Both techniques significantly affected left ventricular function decreasing stroke volume and ejection fraction. In the vertical and rotated position, the ApSD produced a significant decrease from baseline both in stroke volume (DPS: 32.8+/-18.7 vs ApSD: 55.46+/-21.7; p=0.02) and in ejection fraction (DPS: 19.3+/-10.5 vs ApSD: 40.9+/-24.6; p=0.02). The three-dimensional reconstructions demonstrated significant distortion of the atrioventricular geometry and the mitral valve, which was more pronounced with the DPS. CONCLUSION: Both techniques produce variable degrees of deformation with associated cardiac dysfunction and haemodynamic instability. Cardiac function is impeded more with an ApSD with the heart elevated and rotated.
