1.
J Org Chem
; 78(16): 8208-13, 2013 Aug 16.
Article
in English
| MEDLINE
| ID: mdl-23919543
ABSTRACT
A short, 8-step synthesis of the marine natural product pachastrissamine has been developed that relies on a diastereoselective aldol reaction between a suitably protected hydantoin and an optically enriched α-chloroaldehyde. This synthetic route provides new opportunities for exploring structure activity relationships within this family of natural products.
Subject(s)
Sphingosine/analogs & derivatives , Molecular Conformation , Sphingosine/chemical synthesis , Sphingosine/chemistry , Sphingosine/pharmacology
2.
Org Lett
; 15(8): 1914-7, 2013 Apr 19.
Article
in English
| MEDLINE
| ID: mdl-23550817
ABSTRACT
A short synthesis of hydroxyalkyl dihydropyrroles has been developed that involves the coupling of propargylamines with α-chloroaldehydes, followed by Lindlar reduction and a one-pot epoxide formation/opening sequence. The application of this process to the synthesis of unnatural iminosugars and a formal synthesis of (-)-swainsonine is described.