Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
AIDS Behav ; 21(2): 470-480, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27714525

ABSTRACT

Questions remain regarding optimal timeframes for asking about adherence in clinical care. We compared 4-, 7-, 14-, 30-, and 60-day timeframe missed dose items with viral load levels among 1099 patients on antiretroviral therapy in routine care. We conducted logistic and linear regression analyses examining associations between different timeframes and viral load using Bayesian model averaging (BMA). We conducted sensitivity analyses with subgroups at increased risk for suboptimal adherence (e.g. patients with depression, substance use). The 14-day timeframe had the largest mean difference in adherence levels among those with detectable and undetectable viral loads. BMA estimates suggested the 14-day timeframe was strongest overall and for most subgroups although findings differed somewhat for hazardous alcohol users and those with current depression. Adherence measured by all missed dose timeframes correlated with viral load. Adherence calculated from intermediate timeframes (e.g. 14-day) appeared best able to capture adherence behavior as measured by viral load.


Subject(s)
Anti-HIV Agents/therapeutic use , HIV Infections/drug therapy , Medication Adherence , Viral Load , Adult , Alcohol-Related Disorders/epidemiology , Antiretroviral Therapy, Highly Active , Bayes Theorem , Comorbidity , Depressive Disorder/epidemiology , Female , HIV Infections/blood , HIV Infections/epidemiology , HIV Infections/virology , Humans , Linear Models , Logistic Models , Male , Middle Aged , Patient Health Questionnaire , Substance-Related Disorders/epidemiology , Surveys and Questionnaires , Time Factors
2.
AIDS Behav ; 18(12): 2265-73, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25331265

ABSTRACT

Phone-based unannounced pill counts to measure medication adherence are much more practical and less expensive than home-based unannounced pill counts, but their validity has not been widely assessed. We examined the validity of phone versus home-based pill counts using a simplified protocol streamlined for studies embedded in clinical care settings. A total of 100 paired counts were used to compare concordance between unannounced phone and home-based pill counts using interclass correlations. Discrepancy analyses using χ(2) tests compared demographic and clinical characteristics across patients who were concordant between phone and home-based pill counts and patients who were not concordant. Concordance was high for phone-based and home-based unannounced total pill counts, as well as individual medication counts and calculated adherence. This study demonstrates that a simplified phone-based pill count protocol can be implemented among patients from a routine clinical care setting and is a feasible means of monitoring medication adherence.


Subject(s)
Anti-HIV Agents , HIV Infections/drug therapy , House Calls , Medication Adherence , Telephone , Adult , Anti-HIV Agents/therapeutic use , Clinical Protocols , Drug Administration Schedule , Female , House Calls/statistics & numerical data , Humans , Male , Medication Adherence/statistics & numerical data , Middle Aged , Reproducibility of Results , Self Report , Telephone/statistics & numerical data , Washington/epidemiology
3.
J AIDS HIV Res ; 4(2): 47-55, 2012 Feb.
Article in English | MEDLINE | ID: mdl-26561537

ABSTRACT

Providers routinely under diagnose at risk behaviors and outcomes, including depression, suicidal ideation, substance abuse, and poor medication adherence. To address this, we developed a web-based, self-administered patient-reported assessment tool and integrated it into routine primary care for HIV-infected adults. Printed results were delivered to providers and social workers immediately prior to patient appointments. The assessment included brief, validated instruments measuring clinically relevant domains including depression, substance use, medication adherence, and HIV transmission risk behaviors. Utilizing the Institute for Healthcare Improvement's Plan-Do-Study-Act (PDSA) approach to quality improvement, we addressed issues with clinic flow, technology, scheduling, and delivery of assessment results with the support of all levels of clinic staff. We found web-based patient-reported assessments to be a feasible tool that can be integrated into a busy multi-provider HIV primary care clinic. These assessments may improve provider recognition of key patient behaviors and outcomes. Critical factors for successful integration of such assessments into clinical care include: strong top-level /ort from clinic management, provider understanding of patient-reported assessments as a valuable clinical tool, tailoring the assessment to meet provider needs, communication among clinic staff to address flow issues, timeliness of delivery, and sound technological resources.

4.
Int J STD AIDS ; 20(9): 595-600, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19710329

ABSTRACT

Immunization with hepatitis B (HBV) vaccine is recommended for all HIV-infected individuals without immunity to HBV. This patient population, however, has relatively poor HBV vaccine responses. Factors associated with this impaired HBV vaccine response in HIV-infected individuals may include older age, uncontrolled HIV replication, and low nadir CD4 cell count. Postvaccination testing for HBV surface antibody is recommended and vaccine non-responders should undergo repeat immunization with a full series. The benefit of double dosage, the appropriate strategy for HIV-infected patients with isolated HBV core antibody and the timing and number of vaccinations in persons with advanced immunosuppression on highly active antiretroviral therapy remain controversial areas.


Subject(s)
HIV Infections/immunology , Hepatitis B Vaccines/immunology , Vaccination , Adult , CD4 Lymphocyte Count , Humans , Immunization Schedule , Practice Guidelines as Topic , Risk Factors , Time Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...