1.
Org Biomol Chem
; 20(7): 1415-1424, 2022 02 16.
Article
in English
| MEDLINE
| ID: mdl-35014658
ABSTRACT
An expeditious synthetic route to access functionalized pyrrolo[2,1-b]quinazoline scaffolds has been achieved via domino ring opening cyclization (DROC) reactions of donor-acceptor (D-A) cyclopropanes and 2-amino(methyl)aniline derivatives. This novel iron catalyzed transformation is amenable to a wide range of substrates. Three new C-N bonds and two rings were sequentially constructed in this divergent one-pot process. The advantages of simple operation, high yields and general applicability make this procedure highly attractive and practical too.