The psychosocial impact on single mothers' well-being - A literature review.

In India, single-parent families are proliferating. In particular, women are taking the lead in assuming the role. They are the most vulnerable of all the disadvantaged groups. Due to an absence of financial and social support, single mothers endure a great deal of emotional strain. So, the aim of the study is to investigate the various psychosocial factors that influence the well-being of single mothers. Additionally, this research seeks to assess the coping strategies employed by single mothers. This article reviews 80 studies on psychosocial concerns faced by single mothers, focusing on mental health, challenges, and social support. It cites 71 publications from 80 sources from Google Scholar, Scopus, Web of Science, and PubMed, between 1980 and 2023. The study used keywords as a search strategy such as "single mother," "mental health," "challenges," and "social support." The results showed that the absence of financial resources, education, and social support had a negative impact on the emotional and social well-being of single mothers. Children of single mothers are more likely to struggle with addictions like alcoholism, tobacco use, delinquency, hazardous sexual behavior, and even suicidal thoughts due to dysfunctional parenting. As a result, single mothers use their religious convictions, support networks, and social networks as coping mechanisms. The study implies that premarital counseling and health education are essential for young couples to prevent family disintegration in the event of divorce and separation. To provide assistance and improve the overall quality of life for this vulnerable population, collaboration between government and nongovernment organizations is necessary.

A Memory of Early Life Physical Activity Is Retained in Bone Marrow of Male Rats Fed a High-Fat Diet.

Studies have reported opposing effects of high-fat (HF) diet and mechanical stimulation on lineage commitment of the bone marrow stem cells. Yet, how bone marrow modulates its gene expression in response to the combined effects of mechanical loading and a HF diet has not been addressed. We investigated whether early-life (before onset of sexual maturity at 6 weeks of age) voluntary physical activity can modulate the effects of a HF diet on male Sprague Dawley rats. In the bone marrow, early-life HF diet resulted in adipocyte hypertrophy and a pro-inflammatory and pro-adipogenic gene expression profile. The bone marrow of the rats that undertook wheel exercise while on a HF diet retained a memory of the early-life exercise. This memory lasted at least 60 days after the cessation of the voluntary exercise. Our results are consistent with the marrow adipose tissue having a unique response to HF feeding in the presence or absence of exercise.

An expedient sequential one-pot four component synthesis of novel steroidal spiro-pyrrolidine heterocycles in ionic liquid.

A facile one-pot synthesis of novel steroidal dispiro-indenoquinoxaline pyrrolidines via multicomponent-[3+2]-cycloaddition of azomethine ylides in ionic liquid is described. The structure of cycloadduct is confirmed by IR, (1)H NMR, (13)C NMR, high resolution mass spectroscopy and elemental analysis.

Different exercise modalities have distinct effects on the integrin-linked kinase (ILK) and Ca2+ signaling pathways in the male rat bone.

Mechanical loading is essential to maintain optimal skeletal health. Despite the fact that early-life exercise has positive, long-lasting effects on the musculo-skeletal system, the response of the musculo-skeletal system to spontaneous low-impact exercise has been poorly studied. Previously, we identified subtle morphological changes in the femoral diaphysis of exercised animals compared to nonexercised controls. We hypothesized that significant changes in gene expression of cells should precede significant measurable phenotypic changes in the tissues of which they are part. Here, we employed RNA-Seq to analyse the transcriptome of the cortical bone from the femoral mid-diaphysis of prepubertal male Sprague-Dawley rats that were assigned to control (CON); bipedal stance (BPS); or wheel exercise (WEX) groups for 15 days. We identified 808 and 324 differentially expressed transcripts in the BPS and WEX animals respectively. While a number of transcripts change their levels in an exercise-specific manner, we identified 191 transcripts that were differentially expressed in both BPS and WEX. Importantly, we observed that the exercise mode had diametrically opposite effects on transcripts for multiple genes within the integrin-linked kinase (ILK) and Ca(2+) signaling pathways such that they were up-regulated in BPS and down-regulated in WEX. The findings are important for our understanding of possible ways in which different exercise regimens might affect bone when normal activities apply mechanical stimuli during postnatal growth and development.