1.
Org Lett
; 11(24): 5730-3, 2009 Dec 17.
Article
in English
| MEDLINE
| ID: mdl-19928780
ABSTRACT
The asymmetric synthesis of the fully functionalized macrocyclic core of iriomoteolide 3a, a cytotoxic 15-membered macrolide, is disclosed. The key steps involve Sharpless asymmetric dihydroxylation, Sharpless asymmetric epoxidation, olefin cross-metathesis, Yamaguchi esterification, and a ring-closing metathesis reaction for macrocyclization.