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Org Lett ; 11(24): 5730-3, 2009 Dec 17.
Article in English | MEDLINE | ID: mdl-19928780

ABSTRACT

The asymmetric synthesis of the fully functionalized macrocyclic core of iriomoteolide 3a, a cytotoxic 15-membered macrolide, is disclosed. The key steps involve Sharpless asymmetric dihydroxylation, Sharpless asymmetric epoxidation, olefin cross-metathesis, Yamaguchi esterification, and a ring-closing metathesis reaction for macrocyclization.


Subject(s)
Macrolides/chemical synthesis , Cyclization , Dinoflagellida/chemistry , Macrolides/chemistry , Molecular Structure
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