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1.
Bioorg Med Chem Lett ; 17(18): 5256-60, 2007 Sep 15.
Article in English | MEDLINE | ID: mdl-17629699

ABSTRACT

A series of constrained piperidine analogues were synthesized as novel muscarinic M(3) receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M(3) receptor but also have high selectivity over the M(2) receptor.


Subject(s)
Muscarinic Antagonists/chemical synthesis , Muscarinic Antagonists/pharmacology , Receptor, Muscarinic M3/antagonists & inhibitors , Muscarinic Antagonists/chemistry , Structure-Activity Relationship
2.
Bioorg Med Chem Lett ; 2005 Nov 03.
Article in English | MEDLINE | ID: mdl-16275082

ABSTRACT

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

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