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J Med Chem ; 51(8): 2561-70, 2008 Apr 24.
Article in English | MEDLINE | ID: mdl-18361483

ABSTRACT

Pyrano[3,2- c]pyridone and pyrano[3,2- c]quinolone structural motifs are commonly found in alkaloids manifesting diverse biological activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes, we developed compound libraries based on these privileged heterocyclic scaffolds. The selected library members display low nanomolar antiproliferative activity and induce apoptosis in human cancer cell lines. Mechanistic studies reveal that these compounds induce cell cycle arrest in the G2/M phase and block in vitro tubulin polymerization. Because of the successful clinical use of microtubule-targeting agents, these heterocyclic libraries are expected to provide promising new leads in anticancer drug design.


Subject(s)
Biological Products/chemistry , Biological Products/pharmacology , Cell Proliferation/drug effects , Pyridones/chemistry , Pyridones/pharmacology , Quinolones/chemistry , Quinolones/pharmacology , Tubulin/drug effects , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Biological Products/chemical synthesis , Cell Cycle/drug effects , Cell Line, Tumor , Humans , Magnetic Resonance Spectroscopy , Models, Molecular , Pyridones/chemical synthesis , Quinolones/chemical synthesis , Spectrometry, Mass, Electrospray Ionization
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