ABSTRACT
A 61-year-old man presented with aggressive hepatitis. Howell-Jolly bodies were present in circulating erythrocytes and the spleen failed to accumulate intravenously administered Tc-99 m sulfur colloid. The patient thus demonstrated functional asplenia. He was treated with high doses of steroids. Four years later, Howell-Jolly bodies were no longer present in circulating erythrocytes. In addition, the spleen had regained the ability to accumulate intravenously injected radiocolloid. Hence, the patient had reversed his functional asplenia. The reported cases of this disorder (reversible functional asplenia) were reviewed and a preliminary classification was proposed.
Subject(s)
Hepatitis/complications , Spleen/physiopathology , Splenic Diseases/complications , Colloids , Erythrocyte Inclusions/pathology , Hepatitis/physiopathology , Humans , Male , Middle Aged , Prednisone/therapeutic use , Radionuclide Imaging , Spleen/diagnostic imaging , Splenic Diseases/diagnostic imaging , Splenic Diseases/drug therapy , TechnetiumABSTRACT
A gallium-67/technetium-99m subtraction technique was used with a variable weighting factor. That is, each image was separately set to 100%. Varying amounts of the Tc-99m images were subtracted from those of Ga-67. A total of 95 patients who had radiogallium scanning for suspected inflammatory disease were studied by the subtraction technique. Thirty of these patients had abnormal Tc-99m pyrophosphate bone scans, while 20 had abnormal radiogallium abdominal foci; 45 had defects in liver, spleen, or kidney images. The subtraction technique with variable weighting was highly successful in enhancing hot-spot visibility, and in providing information as to the anatomic location of the defect.
Subject(s)
Gallium Radioisotopes , Inflammation/diagnostic imaging , Radionuclide Imaging/methods , Abscess/diagnostic imaging , Adult , Arthritis, Infectious/diagnostic imaging , Citrates , Computers , Diphosphates , Female , Humans , Kidney Diseases/diagnostic imaging , Liver Abscess/diagnostic imaging , Male , Middle Aged , Osteomyelitis/diagnostic imaging , Splenic Diseases/diagnostic imaging , TechnetiumABSTRACT
Two cases are reported in whom there were no circulating polymorphonuclear leukocytes, on peripheral blood smears, at the time when Ga-67 citrate studies were carried out. In both of these women, Ga-67 accumulated at sites of inflammation. This shows that nonpolymorphonuclear pathways are sufficient to deliver Ga-67 and to allow its accumulation. The possible roles of lymphocytes or of noncellular pathways (such as transferrin to tissue lactoferrin) are mentioned.
Subject(s)
Gallium Radioisotopes , Inflammation/metabolism , Neutrophils/physiology , Abscess/diagnostic imaging , Adult , Female , Humans , Lung Diseases, Fungal/diagnostic imaging , Middle Aged , Radionuclide Imaging , Rectal Diseases/diagnostic imagingSubject(s)
Bone and Bones/diagnostic imaging , Kidney Diseases/diagnostic imaging , Technetium , Abdomen , Aged , Diagnosis, Differential , Female , Humans , Kidney Diseases/physiopathology , Radiography , Radionuclide Imaging , Technetium/metabolism , Ureteral Obstruction/diagnostic imaging , Ureteral Obstruction/physiopathologySubject(s)
Abdominal Neoplasms/metabolism , Gallium Radioisotopes/metabolism , Lymphoma/metabolism , Mediastinal Neoplasms/metabolism , Abdominal Neoplasms/diagnostic imaging , Adult , Humans , Liver Diseases/diagnostic imaging , Lymphoma/diagnostic imaging , Male , Mediastinal Neoplasms/diagnostic imaging , Radionuclide Imaging , T-Lymphocytes/metabolism , Technetium , Time FactorsABSTRACT
A patient with clinical, laboratory, radiographic and scintigraphic findings resembling the Budd-Chiari syndrome is described. However, at autopsy there was no thrombotic occlusion of any of the intrahepatic veins. The right hepatic vein was completely constricted by the hypertrophied left lobe of the liver, and the left hepatic vein was narrowed. We have referred to this clinical entity as the pseudo-Budd-Chiari syndrome. It represents a potentially treatable form of the Budd-Chiari syndrome.
