[A new inactivated vaccine against classical swine fever]. / Etude dun nouveau vaccin inactivé contre la peste porcine classique

Authors used a wild strain of classical swine fever virus Alfort A19, grown on PK15 cell culture. Virus is concentrated by ultrafiltration technique, inactivated with glycidaldehyde and then mixed with an oil adjuvant. Results have brought into evidence the absolute innocuousness of this vaccine and animals given 2 doses of 2.5 ml or 1 dose of 5 ml were resistant to a challenge 2 months after vaccination. Protection lasts one year, at least.

[Reversal of the depressive power of cyclophosphamide on the anti-infectious defense of the mouse by means of a somatic antigen from Bacillus subtilis]. / Réversion du pouvoir dépresseur de la cyclophosphamide envers la défense anti-infectieuse de la Souris au moyen d'un antigène somatique de Bacillus subtilis

In the experimental conditions reported the cyclophosphamide increases the pathogenic effect of Escherichia coli in mice. Treating the animals with a somatic antigen of Bacillus subtilis, reverses the aggravating effect of cyclophosphamide on the experimental infection. Similar results are obtained through the parenteral and the rectal routes. This antigen does not limit either the leucopenient effect of cyclophosphamide nor its blocking effect on the synthesis of sheep red blood cells antibody in mice.

[The effect of somatic antigen from Bacillus subtilis on migration of mouse macrophages]. / Etude de l'action d'un antigène somatique de Bacillus subtilis sur la migration des macrophages de souris

The migration of mice peritoneal macrophages has been studied on agar plates. The migration of the macrophages from mice treated by the intra peritoneal route by a somatic antigen of Bacillus subtilis, was 37% less than the migration of the macrophage from control mice. The presence of the antigen in the gel did not modify the migration of macrophages in either treated or control mice. This confirms the non specific character of the activity of this antigen.

[Immunization of ewes against experimental Brucella melitensis infection: comparison of eleven vaccines]. / Immunisation de la brebis contre l'infection expérimentale à Brucella melitensis: comparison de onze vaccins

A comparative study of 11 antibrucellic vaccines has been carried out in the Limousin region of 360 ewe-lambs divided into groups of 30, a 12th group serving as control. After being vaccinated at 8 months, the ewe-lambs were covered between 9 1/2 and 10 1/2 months, then infected at 11 months with Br. melitensis strain 53 H 38 by instillation of 4 x 10(6) germs on the conjonctiva. Six of these vaccines reduced the number of abortions and the excretion of brucella at parturition: three consisted of an inactivated suspension of a virulent S strain of Br. melitensis in oily adjuvant, another consisted of an inactivated suspension of a modified non-agglutinogenic strain of Br. melitensis also in oily adjuvant, the fifth was prepared from Br. melitensis H 105 and Br. abortus B 112 with saponin and the sixth from a strain of Br. melitensis modified with aluminium hydroxide as adjuvant.