Cardiac Phase Detection in Echocardiograms With Densely Gated Recurrent Neural Networks and Global Extrema Loss.

Accurate detection of end-systolic (ES) and end-diastolic (ED) frames in an echocardiographic cine series can be difficult but necessary pre-processing step for the development of automatic systems to measure cardiac parameters. The detection task is challenging due to variations in cardiac anatomy and heart rate often associated with pathological conditions. We formulate this problem as a regression problem and propose several deep learning-based architectures that minimize a novel global extrema structured loss function to localize the ED and ES frames. The proposed architectures integrate convolution neural networks (CNNs)-based image feature extraction model and recurrent neural networks (RNNs) to model temporal dependencies between each frame in a sequence. We explore two CNN architectures: DenseNet and ResNet, and four RNN architectures: long short-term memory, bi-directional LSTM, gated recurrent unit (GRU), and Bi-GRU, and compare the performance of these models. The optimal deep learning model consists of a DenseNet and GRU trained with the proposed loss function. On average, we achieved 0.20 and 1.43 frame mismatch for the ED and ES frames, respectively, which are within reported inter-observer variability for the manual detection of these frames.

A deep learning approach for the analysis of masses in mammograms with minimal user intervention.

We present an integrated methodology for detecting, segmenting and classifying breast masses from mammograms with minimal user intervention. This is a long standing problem due to low signal-to-noise ratio in the visualisation of breast masses, combined with their large variability in terms of shape, size, appearance and location. We break the problem down into three stages: mass detection, mass segmentation, and mass classification. For the detection, we propose a cascade of deep learning methods to select hypotheses that are refined based on Bayesian optimisation. For the segmentation, we propose the use of deep structured output learning that is subsequently refined by a level set method. Finally, for the classification, we propose the use of a deep learning classifier, which is pre-trained with a regression to hand-crafted feature values and fine-tuned based on the annotations of the breast mass classification dataset. We test our proposed system on the publicly available INbreast dataset and compare the results with the current state-of-the-art methodologies. This evaluation shows that our system detects 90% of masses at 1 false positive per image, has a segmentation accuracy of around 0.85 (Dice index) on the correctly detected masses, and overall classifies masses as malignant or benign with sensitivity (Se) of 0.98 and specificity (Sp) of 0.7.