Diagnostic performance of virtual fractional flow reserve derived from routine coronary angiography using segmentation free reduced order (1-dimensional) flow modelling.

INTRODUCTION: Fractional flow reserve (FFR) improves assessment of the physiological significance of coronary lesions compared with conventional angiography. However, it is an invasive investigation. We tested the performance of a virtual FFR (1D-vFFR) using routine angiographic images and a rapidly performed reduced order computational model. METHODS: Quantitative coronary angiography (QCA) was performed in 102 with coronary lesions assessed by invasive FFR. A 1D-vFFR for each lesion was created using reduced order (one-dimensional) computational flow modelling derived from conventional angiographic images and patient specific estimates of coronary flow. The diagnostic accuracy of 1D-vFFR and QCA derived stenosis was compared against the gold standard of invasive FFR using area under the receiver operator characteristic curve (AUC). RESULTS: QCA revealed the mean coronary stenosis diameter was 44% ± 12% and lesion length 13 ± 7 mm. Following angiography calculation of the 1DvFFR took less than one minute. Coronary stenosis (QCA) had a significant but weak correlation with FFR (r = -0.2, p = 0.04) and poor diagnostic performance to identify lesions with FFR <0.80 (AUC 0.39, p = 0.09), (sensitivity - 58% and specificity - 26% at a QCA stenosis of 50%). In contrast, 1D-vFFR had a better correlation with FFR (r = 0.32, p = 0.01) and significantly better diagnostic performance (AUC 0.67, p = 0.007), (sensitivity - 92% and specificity - 29% at a 1D-vFFR of 0.7). CONCLUSIONS: 1D-vFFR improves the determination of functionally significant coronary lesions compared with conventional angiography without requiring a pressure-wire or hyperaemia induction. It is fast enough to influence immediate clinical decision-making but requires further clinical evaluation.

A pilot study showing an association between platelet hyperactivity and the severity of peripheral arterial disease.

Peripheral arterial disease (PAD) is a chronic fibroproliferative inflammatory condition associated with progressive vascular stenosis. We set out to determine the relationship between spontaneous stirring-induced platelet aggregation in whole blood and the severity of lower-limb PAD, represented by the ankle-brachial pressure index (ABPI). ABPI was determined pre- and post-exercise in 31 subjects (20 men and 11 women) with established PAD. Platelets counts were determined in EDTA blood (total count) and in citrated whole blood after stirring in the absence of added ADP (spontaneous aggregation) and in the presence of added ADP (ADP-induced) for 3 min at 37 degrees C. Aggregation was calculated as a percentage of the total platelet count. Spontaneous platelet aggregation showed an inverse correlation with pre-exercise ABPI (r = -0.32; P < 0.05) and ADP-induced aggregation correlated inversely with post-exercise ABPI (r = -0.34; P < 0.05). These results indicate that platelet hyperactivity is associated with increasing severity of PAD. Increased platelet aggregation may result in thromboembolic events in the affected limb.