ABSTRACT
Fibromyalgia syndrome (FMS) is a common form of non-inflammatory rheumatism within the general population with symptoms often mimicking those of arthritis or muscle disorders. Arthralgic symptoms in the region of the hip are commonly mentioned by patients with FMS and one of the diagnostic trigger points for the condition is found around the greater trochanter. To date, no formal imaging studies using ultrasound (US) have been performed in FMS. This study describes the correlation between clinical and US findings in patients presenting with primary FMS to rheumatology clinics. In the majority of the patients, no significant pathological US abnormalities were detected.
Subject(s)
Arthralgia/diagnostic imaging , Fibromyalgia/diagnostic imaging , Hip Joint/diagnostic imaging , Rheumatic Diseases/diagnostic imaging , Adult , Aged , Aged, 80 and over , Arthralgia/etiology , Female , Fibromyalgia/complications , Humans , Male , Middle Aged , Outpatients , Rheumatic Diseases/etiology , Ultrasonography , Young AdultABSTRACT
Over the last ten years, the treatment of seronegative spondyloarthropathies has changed dramatically with the introduction of the anti-tumor necrosis factor alpha (TNFα) agents. Nevertheless, there is a growing number of studies describing several adverse reactions in patients treated with biological agents. In the present report we describe the case of a 22-year-old male patient with ankylosing spondylitis who developed a "paradoxic" adverse reaction, while receiving infliximab.
Subject(s)
Antibodies, Monoclonal/adverse effects , Arthritis/chemically induced , Immunosuppressive Agents/adverse effects , Spondylitis, Ankylosing/drug therapy , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Antibodies, Monoclonal/therapeutic use , Arthritis/blood , Fever/chemically induced , Humans , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/therapeutic use , Infliximab , Male , Methotrexate/administration & dosage , Methotrexate/therapeutic use , Spondylitis, Ankylosing/blood , Young AdultABSTRACT
Gitelman syndrome is a rare inherited tubulopathy, characterized by hypomagnesemia, hypokalemia, metabolic alkalosis, hypocalciuria and hyperreninemic hyperaldosteronism. The clinical spectrum is wide and includes: cramps, myalgias, muscle weakness, until episodes of carpo-podalic spasm, tetania, rhabdomyolysis and paralysis. Some cases have been described in literature underlining the association of this condition with chondrocalcinosis, as a typical example of hypomagnesemia-induced crystal deposition disease. The therapy of Gitelman syndrome consists on the administration of defective electrolytes, although not always effective. We describe two cases of Gitelman syndrome associated with chondrocalcinosis showing the wide range of presentation of this clinical condition.
