ABSTRACT
Complete resolution of a cerebral gumma can take place after massive corticosteroid treatment. Such a result in patients not known as syphilitic can be misleading and hamper the identification of the true nature of the lesion.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Neurosyphilis/drug therapy , Adult , Female , Humans , Magnetic Resonance Imaging , Neurosyphilis/diagnosis , Risk FactorsSubject(s)
Kidney Transplantation , Mouth Neoplasms/etiology , Postoperative Complications , Sarcoma, Kaposi/etiology , Skin Neoplasms/etiology , Adult , Cyclosporins/adverse effects , Female , Humans , Immunosuppression Therapy/adverse effects , Male , Middle Aged , Mouth Neoplasms/pathology , Sarcoma, Kaposi/pathology , Skin Neoplasms/pathologySubject(s)
Angioedema/genetics , Adult , Aged , Angioedema/drug therapy , Angioedema/immunology , Angioedema/pathology , Complement System Proteins/analysis , Female , Humans , Male , Middle Aged , PedigreeSubject(s)
Skin/pathology , Aged , Atrophy/immunology , Atrophy/pathology , Female , Humans , Skin/immunologyABSTRACT
Hereditary angioedema (HAE) is a disease related to a complement disorder, namely a deficiency of C1 esterase inhibitor. Complement-split products are implicated in the regulation of the immune response, and we have compared some immunologic parameters between HAE and normal individuals. T-lymphocytes with receptors for IgG were increased in HAE, but no difference in T-cell suppressor activity for B-cells was detected. Furthermore, increased IgG receptor expression was not accompanied by any significant changes in the ratios of OKT4- and OKT8-defined antigens. Numbers of peripheral mononuclear cells (MNC) detected by alpha-naphthyl acetate esterase (ANAE) staining positivity were not significantly modified in HAE patients, although there was a trend toward higher absolute numbers of them showing paranuclear localization of ANAE. HAE patients had significantly reduced numbers of Langerhans cells (LC) showing different morphology and localization patterns. These observations are discussed in terms of differential membrane arrangements related to particular stages of cell activation, possibly attributable to continual complement activation resulting from a lack of control by C1 esterase inhibitor.