ABSTRACT
Acute coronary thrombosis does not play a major role in the causation of sudden unexpected death due to coronary artery disease. In a study of 500 consecutive autopsies of individuals aged 20-99 years, dying suddenly and unexpectedly of coronary artery disease, only 67 (13.4%) showed an acute thrombosis. In contrast, studies of hospitalized patients with acute transmural infarction of the myocardium showed a rate of coronary artery occlusion > 80%.
Subject(s)
Coronary Disease/complications , Coronary Thrombosis/epidemiology , Death, Sudden, Cardiac/etiology , Adult , Aged , Aged, 80 and over , Coronary Disease/mortality , Coronary Thrombosis/etiology , Coronary Thrombosis/mortality , Coronary Vessels/pathology , Humans , Incidence , Middle Aged , Retrospective StudiesABSTRACT
A study of 1000 consecutive autopsies of individuals dying of natural disease was conducted. Cardiovascular disease was responsible for 60.9% of all deaths with coronary artery disease--not only the main cause of cardiovascular death but also the main cause of all natural deaths--accounting for 45.1% of such cases. Diseases of the central nervous and respiratory systems accounted for 8.7 and 8.6%, respectively, of the natural deaths. Seizure disorders and pneumonia were the main causes of death in these organ systems. There were 124 deaths of children less than one year in age, 91 of which were due to sudden infant death syndrome (SIDS). All of the SIDS deaths were in children less than 10 months old.
