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Neurol Sci ; 24(3): 174-5, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14598073

ABSTRACT

The aim of this study was to assess whether patients with Parkinson's disease (PD) develop cognitive and psychiatric complications more frequently during prolonged therapy with continuous apomorphine infusion compared with standard oral treatment. Thirty consecutive PD patients with severe motor fluctuations were included in the study. Twelve patients accepted the treatment with subcutaneous continuous apomorphine infusion, while the remaining 18 preferred to continue with oral dopaminergic therapy. The two groups were evaluated with neuropsychological, psychiatric, and motor tests at baseline and after 1 year. The off daily duration and the levodopa dosage were significantly reduced in infused patients. The neuropsychiatric assessment did not change in both groups compared with baseline, except for a significant improvement of mood in the apomorphine group.


Subject(s)
Apomorphine/adverse effects , Cognition Disorders/chemically induced , Dopamine Agonists/adverse effects , Parkinson Disease/complications , Aged , Apomorphine/therapeutic use , Dopamine Agonists/therapeutic use , Drug Administration Routes , Drug Administration Schedule , Humans , Levodopa/adverse effects , Longitudinal Studies , Middle Aged , Motor Activity , Neuropsychological Tests , Parkinson Disease/drug therapy , Psychiatric Status Rating Scales
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