ABSTRACT
PURPOSE: Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its a-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS: This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops. RESULTS: Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes. CONCLUSIONS: The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders.(Eur J Ophthalmol 2004; 14: #-13).
ABSTRACT
PURPOSE: Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS: This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops. RESULTS: Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes. CONCLUSIONS: The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders.
Subject(s)
Deoxyepinephrine/analogs & derivatives , Deoxyepinephrine/pharmacology , Glaucoma, Open-Angle/complications , Intraocular Pressure/drug effects , Mydriatics/pharmacology , Pupil/drug effects , Administration, Topical , Aged , Antihypertensive Agents/therapeutic use , Cross-Over Studies , Deoxyepinephrine/administration & dosage , Female , Glaucoma, Open-Angle/diagnosis , Glaucoma, Open-Angle/drug therapy , Humans , Male , Middle Aged , Mydriatics/administration & dosage , Ophthalmic Solutions/administration & dosage , Ophthalmic Solutions/pharmacology , Phenylephrine/administration & dosage , Phenylephrine/therapeutic use , Tonometry, OcularABSTRACT
The authors evaluated the effect of the replacement of beta-blockers with brimonidine drops in patients taking beta-blockers only or with dorzolamide, having IOP > 20 mmHg. The study was divided into two sections: one group treated with brimonidine b.i.d. (23 patients) and the other group treated with brimonidine + dorzolamide b.i.d. (17 patients). The effect of the substitution showed after 90 days of treatment with a reduction of 8.59 +/- 1.2 mmHg (P < 0.001) in the first group and 6.1 +/- 1.7 mmHg (P < 0.001) in the second group. Three patients in the first group and four patients in the second group presented minor adverse effects which did not justify discontinuation of treatment. Brimonidine was effective treatment as a substitute for beta-blockers only when associated with dorzolamide.
Subject(s)
Adrenergic alpha-Agonists/therapeutic use , Adrenergic beta-Antagonists/therapeutic use , Glaucoma, Open-Angle/drug therapy , Intraocular Pressure/drug effects , Quinoxalines/therapeutic use , Aged , Aged, 80 and over , Brimonidine Tartrate , Chronic Disease , Female , Humans , Male , Middle Aged , Prospective Studies , Treatment FailureSubject(s)
Cataract/therapy , Glaucoma, Open-Angle/surgery , Phacoemulsification , Sclerostomy , Trabeculectomy , Aged , Cataract/complications , Glaucoma, Open-Angle/complications , Humans , Intraocular Pressure , Lens Implantation, Intraocular , Prospective Studies , Treatment Outcome , Visual AcuitySubject(s)
Deoxyepinephrine/analogs & derivatives , Dopamine Agonists , Exfoliation Syndrome/complications , Glaucoma/diagnosis , Mydriatics , Aqueous Humor/drug effects , Aqueous Humor/metabolism , Glaucoma/etiology , Humans , Intraocular Pressure/drug effects , Ocular Hypertension/diagnosis , Ocular Hypertension/etiologySubject(s)
Cataract/congenital , Glaucoma/congenital , Adult , Cataract/diagnostic imaging , Ciliary Body/surgery , Follow-Up Studies , Glaucoma/diagnostic imaging , Glaucoma/surgery , Gonioscopy , Humans , Intraocular Pressure , Laser Coagulation , Male , Retinal Detachment/surgery , Scleral Buckling , UltrasonographySubject(s)
Deoxyepinephrine/analogs & derivatives , Deoxyepinephrine/administration & dosage , Mydriatics/administration & dosage , Refraction, Ocular/physiology , Aged , Aged, 80 and over , Female , Humans , Intraocular Pressure/drug effects , Male , Middle Aged , Ophthalmic Solutions , Prospective StudiesABSTRACT
Trans-scleral cyclophotocoagulation is an efficacious method in neovascular glaucoma (NVG) treatment. We have used it with krypton laser on 12 eyes of 12 patients affected by NVG with algetic symptoms. Six months after treatment, intraocular pressure was down enough for the pain to disappear. Executional simplicity and the possibility of modulating the intensity of the treatment are grounds for the encouragement of the technique's use in NVG.
