ABSTRACT
A 12-year-old female neutered cat presented with acute onset unilateral vestibular syndrome, a spontaneous cutaneous wound, polyuria, polydipsia, and diabetes mellitus. Hyperadrenocorticism was demonstrated by means of hyper-responsiveness to adrenocorticotropic hormone stimulation, elevated urine cortisol-to-creatinine ratio, bilaterally enlarged adrenal glands on abdominal ultrasound, and pituitary enlargement on computed tomography imaging. The cat was euthanased and post-mortem histological examination revealed feline skin fragility syndrome; confirmed a pituitary cromophobe macroadenoma; and generalised toxoplasmosis with tachyzoites in the pancreas, bowel and brain. This report is the first to describe the concurrence of macroadenoma pituitary-dependent hyperadrenocorticism and generalised toxoplasmosis in a cat with central vestibular syndrome.
Subject(s)
Adrenocortical Hyperfunction/veterinary , Cat Diseases/diagnosis , Pituitary Neoplasms/veterinary , Toxoplasmosis, Animal/complications , Vestibular Diseases/veterinary , Adrenocortical Hyperfunction/complications , Adrenocortical Hyperfunction/diagnosis , Animals , Cats , Euthanasia, Animal , Female , Pituitary Gland/physiopathology , Pituitary Neoplasms/complications , Pituitary Neoplasms/diagnosis , Toxoplasmosis, Animal/diagnosis , Vestibular Diseases/complicationsABSTRACT
An 18-month-old, female Cane Corso dog was presented with a suspected primary tumor of the tibia. Plain radiographs and computed tomography (CT) of the tibia were highly suggestive of a primary bone neoplasm. A diagnosis of malignant melanoma was made by cytology. Total body survey radiographs, CT scan of the thorax, and abdominal ultrasound excluded the presence of neoplastic lesions other than in the tibia. Limb amputation was performed. Histology and immunohistochemical analysis of the tibial neoplasm confirmed the diagnosis of a melanoma with secondary metastasis to the popliteal lymph node. The dog was alive and in good physical condition 43 months after surgery.
