ABSTRACT
UNLABELLED: The effects of intracoronary infusion (24 ml/min) of oxygenated perfluoroocytlbromide (PFOB) or autologous blood on regional myocardial function and hemodynamics were studied during a 2 min perfused occlusion in nine open chest dogs to determine if a PFOB infusion could prevent the myocardial dysfunction observed during the balloon occlusion of percutaneous transluminal coronary angioplasty (PTCA). Regional myocardial function was measured with sonomicrometers in the ischemic and non-ischemic zone to determine segment length and percent of systolic shortening (% delta L). Without infusion, the ischemic zone in each animal developed akinesis during a 20 sec coronary occlusion. Each animal underwent a 2 min infusion of blood and PFOB at 24 ml/min. During the 2 min perfused occlusion, the blood ischemic zone % delta L of 14.4 +/- 3.1 versus a PFOB % delta L of 23.4 +/- 2.9. % delta L of blood and PFOB were not as significantly different from control (P less than .05 PFOB vs. blood). The bromine ion in PFOB results in a radiodense compound. Adequate images of the canine left ventricle and coronaries were obtained using DSA. CONCLUSION: (1) PFOB infusion maintains normal myocardial function during perfused coronary inclusion. (2) PFOB may be used as an oxygen carrying contrast agent to obtain DSA images.
