ABSTRACT
A study of patients with pulmonary hypertension caused by chronic inflammatory pulmonary diseases revealed that ibuprofen may induce an elevation of the pressure in the lesser circulation that is most probably connected with inhibition of synthesis of prostacyclin and prostaglandins of type E.
Subject(s)
Hypertension, Pulmonary/drug therapy , Ibuprofen/therapeutic use , Vasoconstrictor Agents , Adult , Cardiac Catheterization , Drug Evaluation , Female , Humans , Hypertension, Pulmonary/physiopathology , Male , Middle Aged , Pulmonary Circulation/drug effects , Respiratory Function Tests , Time FactorsSubject(s)
Molsidomine/therapeutic use , Pulmonary Heart Disease/drug therapy , Acid-Base Equilibrium/drug effects , Adult , Aged , Blood Gas Analysis , Chronic Disease , Drug Evaluation , Female , Hemodynamics/drug effects , Humans , Male , Middle Aged , Pulmonary Heart Disease/blood , Pulmonary Heart Disease/physiopathology , Respiration/drug effectsABSTRACT
Patients with acute pneumonia demonstrate disturbance of myocardial contractility manifesting itself in an increase of end diastolic and systolic volumes, a decrease in the ejection fraction and circular myocardial contractility rate. In a raised level of mean arterial pressure i.v. administration of strophanthin in acute pneumonia can produce a negative effect in the form of a decrease in the stroke volume and cardiac output. Myofedrin promotes an increase in cardiac ejection and can be used for therapy of patients with acute pneumonia to correct hemodynamics.
