Subject(s)
Glare , Vision Disorders/diagnosis , Vision Tests , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Humans , Middle Aged , Vision Disorders/physiopathology , Visual AcuityABSTRACT
Metamphocin (methyl ether of amphotericin B), a new antifungal polyene antibiotic was used in the treatment of ocular mycoses. The procedure and results of its use are described. The clinical trials included 8 patients with keratomycosis and 2 patients with fungal endophthalmitis. Metamphocin was administered as drop-like intravenous injections in combination with local instillation of ketoconazole and dexamethasol. The clinical trials showed that metamphocin was an efficient antifungal drug useful in the treatment of ocular mycoses. Metamphocin proved to be less toxic than amphotericin B.
Subject(s)
Amphotericin B/analogs & derivatives , Antifungal Agents/therapeutic use , Eye Infections, Fungal/drug therapy , Amphotericin B/therapeutic use , Corneal Diseases/drug therapy , Dexamethasone/therapeutic use , Drug Therapy, Combination , Endophthalmitis/drug therapy , Humans , Ketoconazole/therapeutic useABSTRACT
The method and results of the use of itrakonazol, a new antifungal agent of the imidazol class, in the treatment of fungal diseases of the eye are described. The clinical trials involved 50 patients with various clinical forms of ophthalmomycosis: 27 patients with fungal affection of the cornea, 3 patients with fungal endophthalmitis, 8 patients with fungal canaliculitis, 3 patients with fungal blepharitis and 9 patients with fungal conjunctivitis. The clinical trials showed that itraconazole had a sufficiently high antifungal activity in the treatment of the ophthalmomycoses. The drug is low toxic and well tolerated.
Subject(s)
Eye Infections, Fungal/drug therapy , Itraconazole/therapeutic use , Blepharitis/drug therapy , Conjunctivitis/drug therapy , Corneal Diseases/drug therapy , Endophthalmitis/drug therapy , Humans , Itraconazole/adverse effectsABSTRACT
The use of a new class of broad spectrum antifungal drugs i.e. imidazoles and in particular ketoconazole in treatment of severe affections of the eye such as mycoses is described. The clinical trials included 40 patients with various forms of mycosis: mycotic canaliculitis (6 patients), mycotic blepharitis (4 patients), mycotic conjunctivitis (7 patients), keratomycosis (17 patients) and mycotic endophthalmitis (6 patients). Ketoconazole was used in the form of tablets and instillations. The combined treatment included nonsteroid antiinflammatory drugs and antibacterial agents. The clinical trials showed that ketoconazole had pronounced antifungal activity and was rather efficient in treatment of ocular mycoses. Its broad spectrum and low toxicity were recorded.
Subject(s)
Aspergillosis/drug therapy , Candidiasis/drug therapy , Eye Infections, Fungal/drug therapy , Ketoconazole/administration & dosage , Administration, Oral , Humans , Ophthalmic Solutions , Penicillium chrysogenumABSTRACT
The paper describes the method and results of using a nonsteroid anti-inflammatory preparation RENGAZYL in a complex treatment of severe forms of ophthalmic herpes-keratitis with ulcerations. Comparative clinical studies included 81 patients divided into 3 groups. The complex treatment used preparations of antiviral, anti-inflammatory, antiedematous, hypotensive, desensitizing and vitamin therapy. In group 1 (28 patients) rengazyl in capsules was used, in group 2 (24 patients)--intramuscular injections of rengazyl. In group 3 (29 patients) indometacine in pills was used. The clinical results obtained have shown that rengazyl in a form of intramuscular injections possesses expressed anti-inflammatory action in case of the most severe forms of ophthalmic herpes. Besides this, rengazyl possesses analgetic action that makes it more preferable in treatment of inflammations of the choroid accompanied by a pronounced algesic syndrome.
