1.
Thorax
; 75(9): 801-804, 2020 09.
Article
in English
| MEDLINE
| ID: mdl-32482837
ABSTRACT
CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI -20 to -8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI -21 to -10). CT imaging may improve candidate risk stratification.
Subject(s)
Adiposity , Lung Diseases/surgery , Lung Transplantation , Muscle, Skeletal/diagnostic imaging , Abdominal Wall/diagnostic imaging , Aged , Cohort Studies , Female , Humans , Lung Diseases/mortality , Lung Diseases/physiopathology , Male , Middle Aged , Muscle, Skeletal/physiopathology , Risk Assessment , Survival Rate , Thigh/diagnostic imaging , Tomography, X-Ray Computed , Treatment Outcome , Waiting Lists/mortality , Walk Test
2.
Transplantation
; 101(1): 21-22, 2017 01.
Article
in English
| MEDLINE
| ID: mdl-28009755