Prognostic values of preoperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio for patients with muscle-invasive bladder cancer undergoing radical cystectomy / Prognostic values of preoperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and lymphocyte- to-monocyte ratio for patients with muscle- invasive bladder cancer undergoing radical cystectomy

OBJECTIVE: To study the prognostic values of preoperative neutrophil-to-lymphocyteratio (NLR), platelet-to-lymphocyte ratio (PLR) andlymphocyte-to-monocyte ratio (LMR) for patients withmuscle-invasive bladder cancer (MIBC) undergoingradical cystectomy.METHODS: The clinical data of 186 MIBC patientsreceiving radical cystectomy from January 2013 toOctober 2015 were collected. Receiver operating characteristic (ROC) curves were plotted based on preoperative NLR, PLR and LMR as well as survival of patientswithin 5 years after surgery. The NLR, PLR and LMRvalues of patients with different clinicopathological characteristics were described by frequencies.Recurrence-free survival curve was plotted using theKaplan-Meier method, and survival curves were compared by the log-rank test. Independent risk factorsfor recurrence were explored by multivariate logistic regression analysis. NLR, PLR and LMR were utilizedto establish the recurrence risk scoring model, and theaccuracy for predicting recurrence was assessed byROC curves.RESULTS: NLR groups had significantly differentpathological grade, T stage, lymph node metastasis and tumor number. The differences in age,pathological grade, T stage, lymph node metastasisand tumor number were significant between PLRgroups. Gender, pathological grade, T stage, lymphnode metastasis, tumor number and tumor sizehad significant differences between LMR groups(P<0.05). There were significant differences in recurrence-free survival rate between NLR≥2.45 andNLR<2.45 groups (30.21% vs. 71.11%), PLR≥157.3and PLR<157.3 groups (26.73% vs. 77.65%), andLMR≥3.72 and LMR<3.72 groups (79.10% vs.33.61%) (P<0.001). Pathological grade, T stage,tumor number, lymph node metastasis, NLR, PLRand LMR were independent risk factors for MIBCpatients. After these factors were included into therecurrence risk scoring model, the area under ROCcurve was 0.821.CONCLUSIONS: Preoperative NLR, PLR and LMR are potential biomarkers

OBJETIVOS: Estudiar el valor pronóstico del índice neutrófilo-linfocito (INL), plaqueta-linfocito (IPL) y linfocito-monocito (ILM) preoperatorioen pacientes con Cáncer de Vejiga Músculo Invasivo(CVMI) sometidos a cistectomía radical.MÉTODOS: Se analizaron los datos clínicos de 186pacientes con CVMI sometidos a cistectomía desdeEnero 2013 a Octubre 2015. Se ejecutaron curvasReceiver operating characteristics (ROC) basadas enel valor preoperatorio de INL, IPL, ILM así como la supervivencia a los 5 años de la cirugía. Los valores delos INR, IPL, ILM de los pacientes con diferentes características clínicopatológicas se describieron mediantefrecuencias. Se obtuvo una curva de supervivencia libre de recurrencia usando el método de Kaplan-Meier,mientras que las curvas de supervivencias se compararon con el log-rank test. Se exploraron los factoresindependientes de recurrencia a través de un análisisde regresión logística. Se usaron los INL, IPL, ILM paraestablecer un modelo predictive de riesgo de recurrencia cuya precision fue evaluada con curvas ROC.RESULTADOS: Las diferencias fueron significativaspara los grupos INL en cuanto a grado histológico,estadio tumoral, metastasis ganglionares y númerode tumores. Las diferencias en edad, grado histológico, estadio tumoral, metastasis a ganglios linfáticosy número de tumores fueron significativas entre losgrupos IPL. Mientras que en los grupos ILM las diferencias fueron significativas en género, grado histológico, estadio tumar, metastasis a ganglios linfáticos,número y tamaño tumoral. (P<0.05). Hubo diferenciassignificativas en la tasa de recurrencia libre de enfermedad en los grupos INL≥2.45 e INL<2.45 (30.21% vs.71.11%), los grupos IPL≥157.3 e IPL<157.3 (26.73% vs.77.65%), y los grupos ILM≥3.72 e ILM<3.72 (79.10%vs. 33.61%) (P<0.001). El grado histológico, estadio tumoral, número de tumores, metastasis ganglionares,INL, IPL, ILM fueron factores de riesgo independientesen pacientes con CVMI. Después

Effects of aerosolized prostaglandin E1 before one lung ventilation on lung protection in patients undergo-ing surgery for oesophageal cancer / 临床麻醉学杂志

Objective To observe the effects of aerosolized prostaglandin E1 (PGE1 )via right lung before one-lung ventilation (OLV ) on shunt rate (Qs/Qt ) and oxygenation in patients undergoing surgery for oesophageal cancer.Methods Sixty patients scheduled for elective trans-left-thoracic esophagectomy for esophageal cancer were randomly and single-blindly located into two groups.Patients in each group received different therapy before OLV,namely inhaling PGE1 0.2μg/kg via right lung in group P and inhaling normal saline in group C.The PaO 2 and hemodynamic indicators of two groups were recorded at these points:before OLV(T1 ),OLV 10 min (T2 ),OLV 1 5 min (T3 ),OLV 30 min (T4 ),OLV 60 min (T5 ),OLV 120 min (T6 ),.Results PaO 2 in both groups were declined straightly since OLV and fell to the lowest point at T4 in group C.PaO 2 in group P at T2-T4 were significantly higher than that in group C (P <0.05),and the lowest point of which was recorded at T5 .Qs/Qt in group P was significantly lower than that in group C at T2-T4 (P <0.05).There were no significant differences in hemodynamics indicators between the two groups. Conclusion Inhalation of 0.2 μg/kg PGE1 before OLV via one lung can reduce pulmonary shunt and improve PaO 2 in thoracic surgery patients.