[The pharmacological correction of recurrent immediate-type allergic reactions]. / Farmakologicheskaia korrektsiia povtornykh allergicheskikh reaktsii nemedlennogo tipa.

The effect of drugs on the early and late phases of repeated allergic reactions (RAR) was studied in experiments on rabbits. The action of the drugs was estimated by the number of challenge doses of antigen, endured by survived and dead rabbits, percentage of the animals' death, and by the place of each group on the lethality scale. Diphenhydramine, ouabain and their combinations, silver nitrate (20 mg/kg) and DOCA enhanced whereas histamine, unithiol, cholesterol, and silver nitrate (20 and 0.2 mg/kg) decreased allergization in the period of RAR. The characteristic features of the action of the drugs on RAR were revealed and compared to the first allergic reaction. Qualitative and quantitative differences were shown in the action of different drug doses and combinations on RAR. The authors provide evidence for the possibility of treating allergic diseases by drug administration in a quiet period.

[Effect of some steroidal compounds on the development of an immediate allergic reaction]. / Vliianie nekotorykh steroidnykh soedinenii na razvitie nemedlennoi allergicheskoi reaktsii.

In experiments on rabbits various effects of steroidal agents (hydrocortisone, deoxycorticosterone, beta-lipoproteids, cholesterol, saponins, digitoxin, strophanthin) on the development of sensitization and allergization at their administration during sensitization and before the resolving dose of the antigen were shown.

[Effect of antihistamine preparations and histamine on the development of allergic processes]. / Vliianie protivogistaminnykh preparatov i gistamina na razvitie allergicheskikh protsessov.

The effect of antihistaminic drugs, histamine and their combinations on the development of anaphylactic shock and the period of repeated resolution doses was studied in rabbit experiments. It was established that administration of dimedrol during sensibilization aggravated while diazolin and histamine attenuated the course of anaphylactic shock and periods of repeated resolution injections. Simultaneous administration of antihistaminic agents and histamine enhanced the allergization of the body. Under conditions reported dimedrol prevented hypertrophy of the adrenals that occurred in response to sensibilization. Meanwhile diazolin did not interfere with the reaction development and histamine stimulated it. Combined administration of the antihistaminic agents and histamine provoked an inhibition of the above reaction of the adrenals to body sensibilization.