Effects of Subthalamic Stimulation on Olfactory Function in Parkinson Disease.

BACKGROUND: Olfactory dysfunction is a nonmotor symptom of Parkinson disease (PD) associated with reduction in quality of life. There is no evidence on whether improvements in olfaction after subthalamic deep brain stimulation (STN-DBS) may be directly attributable to motor improvement or whether this reflects a direct effect of DBS on olfactory brain areas. The aim of the present study was to evaluate the effect of DBS on olfactory function in PD, as well as to explore the correlation between these changes and changes in motor symptoms and brain metabolism. METHODS: Thirty-two patients with PD were screened for STN-DBS. Patients were evaluated before and 1 year after surgery. Primary outcome was the change in olfactory function (Sniffin' Sticks odor-identification test [SST]) after surgery among the patients with hyposmia at baseline. Secondary outcomes included the relationship between motor outcomes and olfactory changes and [18F]fluorodeoxyglucose-positron emission tomography analysis between subgroups with improvement versus no improvement of smell. RESULTS: STN-DBS improved SST after surgery (preoperative SST, median 7.3 ± 2.4 vs. postoperative SST, median 8.2 ± 2.1; P = 0.045) in a subset of patients among 29 of 32 patients who presented with hyposmia at baseline. The improvement in SST was correlated with DBS response (r = 0.424; P = 0.035). There was also an increase in glucose metabolism in the midbrain, cerebellum, and right frontal lobe in patients with SST improvement (P < 0.001). CONCLUSIONS: STN-DBS improves odor identification in a subset of patients with PD. Motor improvement together with changes in the brain metabolism may be linked to this improvement.

Telerehabilitation in Parkinson's disease: Influence of cognitive status / Telerehabilitação na doença de Parkinson: influência do estado cognitivo

ABSTRACT Background: The need for efficacy in voice rehabilitation in patients with Parkinson's disease is well established. Given difficulties traveling from home to treatment centers, the use of telerehabilitation may represent an invaluable tool for many patients. Objective: To analyze the influence of cognitive performance on acceptance of telerehabilitation. Methods: Fifty patients at stages 2-4 on the Hoehn-Yahr scale, aged 45-87 years old, with cognitive scores of19-30 on the Mini-Mental State Examination, and 4-17 years of education were enrolled. All patients were submitted to evaluation of voice intensity pre and post in-person treatment with the Lee Silverman Voice Treatment (LSVT) and were asked to fill out a questionnaire regarding their preferences between two options of treatment and evaluating basic technological competence. Results: Comparisons between pre and post-treatment values showed a mean increase of 14dBSPL in vocal intensity. When asked about potential acceptance to participate in future telerehabilitation, 38 subjects agreed to take part and 12 did not. For these two groups, 26% and 17% self-reported technological competence, respectively. Agreement to engage in remote therapy was positively associated with years of education and cognitive status. Conclusion: Responses to the questionnaire submitted after completion of traditional in-person LSVT showed that the majority of patients (76%) were willing to participate in future telerehabilitation. Age, gender, disease stage and self-reported basic technological skills appeared to have no influence on the decision, whereas other factors such as cognitive status and higher school education were positively associated with acceptance of the new therapy approach.

RESUMO Embasamento: A eficácia na reabilitação da voz em pacientes com doença de Parkinson está bem estabelecida. Tendo em vista as dificuldades de lidar com a locomoção de casa para centros de tratamento, o uso da telerreabilitação pode representar uma ferramenta inestimável para muitos pacientes. Objetivo: Analisar a influência do desempenho cognitivo na aceitação da telerreabilitação. Métodos: Participaram cinquenta pacientes em estágios 2-4 de acordo com a escala de Hoehn-Yahr, com idade entre 45 e 87 anos, escores cognitivos de 19 a 30 no Mini-Exame do Estado Mental e escolaridade entre 4-17 anos. Todos foram submetidos à avaliação da intensidade da voz antes e depois do tratamento pelo Lee Silverman Voice Treatment (LSVT) e foram convidados a responder um questionário sobre suas preferências entre duas opções de tratamento. Resultados: O tratamento resultou em aumento médio de 14dBNPS. Quando questionados sobre a possibilidade de aceitação para participar de um futuro programa de telerreabilitação, 38 indivíduos concordaram e 12 não. Em relação a estes dois grupos, a competência tecnológica foi referida em 26% e 17%, respectivamente. A aceitação à telerreabilitação foi positivamente relacionada com anos de estudo e estado cognitivo. Conclusão: As respostas ao Questionário após a conclusão do LSVT tradicional mostraram que a maioria dos pacientes (76%) concordaria em participar de uma futura telerreabilitação. Idade, sexo, estágio da doença ou competência tecnológica não pareceu influenciar na adesão à telerreabilitação enquanto que outros fatores, como estado cognitivo e anos de escolaridade foram positivamente relacionados com a aceitação da nova forma de terapia.

Voice telerehabilitation in Parkinson's disease. / Telerreabilitação vocal na doença de Parkinson.

UNLABELLED: Parkinson's disease (PD) is a neurodegenerative condition associated with motor, neuropsychological, sensorial, and vocal symptoms. It has been suggested that eventual obstacles faced by many patients to reach speech therapy rehabilitation centers could be overcome with the use of synchronous telerehabilitation (real time) approach employing communication technologies. PURPOSE: To investigate the efficacy of vocal telerehabilitation in PD patients. METHODS: Twenty patients diagnosed with PD and with vocal complaints participated in this study. Patients were evaluated by videoconference (Adobe Connect 8) before and after treatment. Evaluation method consisted of perceptual analysis of vocal quality measured by the GRBASI scale. Treatment was conducted following the extended version of Lee Silverman method (LSVT-X). At the end of treatment all patients were requested to fill a questionnaire to assess their experience with telerehabilitation. RESULTS: Analysis revealed decrease in magnitude of voice quality changes after the intervention, indicating improvement of vocal pattern. All patients reported satisfaction and preference for telerehabilitation compared to face-to-face rehabilitation, as well as positive perception of audio and video. Some technological adversities have been identified but did not prevent the approaches to assessment and treatment. CONCLUSION: Present results suggest that telerehabilitation methods can be considered as an effective treatment for speech symptoms associated with PD and can be indicated to patients presenting limited access to speech therapy centers and technological readiness.

Telerreabilitação vocal na doença de Parkinson / Voice telerehabilitation in Parkinson's disease

RESUMO A doença de Parkinson (DP) é uma moléstia neurodegenerativa associada a significantes prejuízos motores, neuropsicológicos e sensoriais. Alterações na qualidade da voz são frequentes durante o curso da doença e os pacientes enfrentam obstáculos no acesso a serviços de reabilitação fonoaudiológica adequada. A telerreabilitação é uma possível solução para esse problema, uma vez que pode ser implementada a distância, com recursos de telemedicina, via tecnologias de comunicação e informação. Objetivo: Investigar a eficiência da telerreabilitação da voz em pacientes com DP. Métodos: Participaram 20 pacientes com DP e queixas de voz. A telerreabilitação síncrona (em tempo real) ocorreu a partir de videoconferência (Adobe Connect 8), os pacientes foram telerreabilitados pela versão estendida do Lee Silverman Voice Treatment (LSVT-X) e avaliados, antes e depois dessa intervenção por meio de análise perceptual da qualidade vocal pela Escala GRBASI. No final da intervenção, todos responderam a questionário estruturado sobre a experiência com a telerreabilitação. Resultados: As análises revelaram diminuição na magnitude das alterações da qualidade da voz após a intervenção, indicando melhoria do padrão vocal. Todos os pacientes relataram satisfação e preferência pela telerreabilitação em comparação com a reabilitação presencial, assim como positiva percepção de áudio e vídeo. Algumas adversidades tecnológicas foram identificadas, mas não impediram as abordagens de avaliação e tratamento. Conclusão: Os resultados sugerem que a telerreabilitação seja uma intervenção eficiente para os sintomas da qualidade da voz associados à DP e pode ser indicada para pacientes com acesso a tecnologias e dificuldades no alcance de profissionais ou centros especializados.

ABSTRACT Parkinson’s disease (PD) is a neurodegenerative condition associated with motor, neuropsychological, sensorial, and vocal symptoms. It has been suggested that eventual obstacles faced by many patients to reach speech therapy rehabilitation centers could be overcome with the use of synchronous telerehabilitation (real time) approach employing communication technologies. Purpose: To investigate the efficacy of vocal telerehabilitation in PD patients. Methods: Twenty patients diagnosed with PD and with vocal complaints participated in this study. Patients were evaluated by videoconference (Adobe Connect 8) before and after treatment. Evaluation method consisted of perceptual analysis of vocal quality measured by the GRBASI scale. Treatment was conducted following the extended version of Lee Silverman method (LSVT-X). At the end of treatment all patients were requested to fill a questionnaire to assess their experience with telerehabilitation. Results: Analysis revealed decrease in magnitude of voice quality changes after the intervention, indicating improvement of vocal pattern. All patients reported satisfaction and preference for telerehabilitation compared to face-to-face rehabilitation, as well as positive perception of audio and video. Some technological adversities have been identified but did not prevent the approaches to assessment and treatment. Conclusion: Present results suggest that telerehabilitation methods can be considered as an effective treatment for speech symptoms associated with PD and can be indicated to patients presenting limited access to speech therapy centers and technological readiness.

Speech disorders did not correlate with age at onset of Parkinson's disease.

Speech disorders are common manifestations of Parkinson´s disease. Objective To compare speech articulation in patients according to age at onset of the disease. Methods Fifty patients was divided into two groups: Group I consisted of 30 patients with age at onset between 40 and 55 years; Group II consisted of 20 patients with age at onset after 65 years. All patients were evaluated based on the Unified Parkinson's Disease Rating Scale scores, Hoehn and Yahr scale and speech evaluation by perceptual and acoustical analysis. Results There was no statistically significant difference between the two groups regarding neurological involvement and speech characteristics. Correlation analysis indicated differences in speech articulation in relation to staging and axial scores of rigidity and bradykinesia for middle and late-onset. Conclusions Impairment of speech articulation did not correlate with age at onset of disease, but was positively related with disease duration and higher scores in both groups.

Speech disorders did not correlate with age at onset of Parkinson's disease / Distúrbios da fala não se correlacionam com a idade de início da doença de Parkinson

ABSTRACT Speech disorders are common manifestations of Parkinson´s disease. Objective To compare speech articulation in patients according to age at onset of the disease. Methods Fifty patients was divided into two groups: Group I consisted of 30 patients with age at onset between 40 and 55 years; Group II consisted of 20 patients with age at onset after 65 years. All patients were evaluated based on the Unified Parkinson’s Disease Rating Scale scores, Hoehn and Yahr scale and speech evaluation by perceptual and acoustical analysis. Results There was no statistically significant difference between the two groups regarding neurological involvement and speech characteristics. Correlation analysis indicated differences in speech articulation in relation to staging and axial scores of rigidity and bradykinesia for middle and late-onset. Conclusions Impairment of speech articulation did not correlate with age at onset of disease, but was positively related with disease duration and higher scores in both groups.

RESUMO Distúrbios da fala são comuns da doença de Parkinson. Objetivo Comparar a articulação da fala de acordo com a idade de início da doença. Métodos Cinquenta pacientes foram divididos em dois grupos: Grupo I consistiu de 30 pacientes com idade de início entre 40 e 55 anos; Grupo II foi composto por 20 pacientes com idade de início após os 65 anos. Todos foram avaliados pela Unified Parkinson’s Disease Rating Scale, Hoehn and Yahr e análise perceptual e acústica da fala. Resultados Não houve diferença estatística significativa entre os dois grupos quanto às características neurológicas e de fala. Análises de correlação indicaram diferença estatística significativa entre articulação da fala, estágio da doença e escores axiais, de rigidez e bradicinesia. Conclusões A articulação da fala não se correlacionou com a idade de início da doença, mas foi positivamente relacionada à duração da doença e aos escores mais elevados nos dois grupos.

Telerehabilitation in Parkinson's disease: Influence of cognitive status.

BACKGROUND: The need for efficacy in voice rehabilitation in patients with Parkinson's disease is well established. Given difficulties traveling from home to treatment centers, the use of telerehabilitation may represent an invaluable tool for many patients. OBJECTIVE: To analyze the influence of cognitive performance on acceptance of telerehabilitation. METHODS: Fifty patients at stages 2-4 on the Hoehn-Yahr scale, aged 45-87 years old, with cognitive scores of19-30 on the Mini-Mental State Examination, and 4-17 years of education were enrolled. All patients were submitted to evaluation of voice intensity pre and post in-person treatment with the Lee Silverman Voice Treatment (LSVT) and were asked to fill out a questionnaire regarding their preferences between two options of treatment and evaluating basic technological competence. RESULTS: Comparisons between pre and post-treatment values showed a mean increase of 14dBSPL in vocal intensity. When asked about potential acceptance to participate in future telerehabilitation, 38 subjects agreed to take part and 12 did not. For these two groups, 26% and 17% self-reported technological competence, respectively. Agreement to engage in remote therapy was positively associated with years of education and cognitive status. CONCLUSION: Responses to the questionnaire submitted after completion of traditional in-person LSVT showed that the majority of patients (76%) were willing to participate in future telerehabilitation. Age, gender, disease stage and self-reported basic technological skills appeared to have no influence on the decision, whereas other factors such as cognitive status and higher school education were positively associated with acceptance of the new therapy approach.

EMBASAMENTO: A eficácia na reabilitação da voz em pacientes com doença de Parkinson está bem estabelecida. Tendo em vista as dificuldades de lidar com a locomoção de casa para centros de tratamento, o uso da telerreabilitação pode representar uma ferramenta inestimável para muitos pacientes. OBJETIVO: Analisar a influência do desempenho cognitivo na aceitação da telerreabilitação. MÉTODOS: Participaram cinquenta pacientes em estágios 2-4 de acordo com a escala de Hoehn-Yahr, com idade entre 45 e 87 anos, escores cognitivos de 19 a 30 no Mini-Exame do Estado Mental e escolaridade entre 4-17 anos. Todos foram submetidos à avaliação da intensidade da voz antes e depois do tratamento pelo Lee Silverman Voice Treatment (LSVT) e foram convidados a responder um questionário sobre suas preferências entre duas opções de tratamento. RESULTADOS: O tratamento resultou em aumento médio de 14dBNPS. Quando questionados sobre a possibilidade de aceitação para participar de um futuro programa de telerreabilitação, 38 indivíduos concordaram e 12 não. Em relação a estes dois grupos, a competência tecnológica foi referida em 26% e 17%, respectivamente. A aceitação à telerreabilitação foi positivamente relacionada com anos de estudo e estado cognitivo. CONCLUSÃO: As respostas ao Questionário após a conclusão do LSVT tradicional mostraram que a maioria dos pacientes (76%) concordaria em participar de uma futura telerreabilitação. Idade, sexo, estágio da doença ou competência tecnológica não pareceu influenciar na adesão à telerreabilitação enquanto que outros fatores, como estado cognitivo e anos de escolaridade foram positivamente relacionados com a aceitação da nova forma de terapia.

Características fonoarticulatórias na doença de Parkinson de início na meia idade e tardio / Speech and voice characteristics in middle age and late onset Parkinson's disease

A DP pode acarretar alterações fonoarticulatórias. Objetivo: Comparar e correlacionar aspectos fonoarticulatórios de pacientes com DP de início na meia idade e tardio. Método: 50 pacientes divididos em dois grupos de acordo com a idade início da DP realizaram avaliação neurológica e fonoaudiológica. Resultados: Não houve diferença estatística entre os dois grupos. Houve diferença em algumas correlações Conclusões: A idade de início não influenciou os aspectos analisados. Qualidade, f0, intensidade vocal e velocidade da fala foram semelhantes nos estágios da DP...

PD may develop speech and voice abnormalities. Objective: To compare speech and voice manifestations in PD patients with middle-age and late-onset disease. Methods: 50 patients were divided into two groups and submitted to neurological plus speech and voice evaluation. Results: There was no statistically significant difference between the groups. Had difference in some correlations. Conclusion: The age of onset did not influence the speech and voice manifestations analysed. The imprecise speech type was associated with higher scores for axial symptoms, while speech intelligibility abnormalities were associated not only with higher scores for axial symptoms, but also with rigidity and bradykinesia...

[Treatment of vocal symptoms in Parkinson's disease: the Lee Silverman method]. / Tratamento dos distúrbios da voz na doença de Parkinson: o método Lee Silverman.

Mild changes in voice quality and articulation of speech may be seen in early phases of Parkinson's disease (PD). Voice and speech disturbances in PD constitute a hypocinetic dysarthria or dysarthrophonia and are characterized by monotony and reduced intensity of voice, imprecise articulation and disturbances of rhythm. Favorable results with an intensive method (Lee Silverman Voice Treatment) for the treatment of voice disturbances in PD were recently reported. The main goal of the method is to augment vocal intensity through the increment of phonatory effort. The purpose of the present study was to characterize vocal abnormalities (hoarseness, breathiness, articulatory pattern and inteligibility) in a group of patients with PD and to evaluate the therapeutic efficacy of the Lee Silverman method. Acoustic as well as perceptive-auditory analysis showed statistically significant differences between pre and post treatment groups. Although the articulatory pattern has not considerably changed, the benefits obtained with the improvement in vocal quality positively influenced overall quality of oral communication.

Tratamento dos distúrbios da voz na doença de Parkinson. O método Lee Silverman / Treatment of vocal symptoms in Parkinson's disease: the Lee Silverman method

Alterações discretas na qualidade da voz e da articulaçäo podem ser observadas em fases relativamente iniciais da doença de Parkinson (DP). As alterações da voz e da fala na DP constituem, em conjunto, o que se denomina disartria hipocinética ou disartrofonia e caracterizam-se por monotonia e reduçäo da intensidade da voz, articulaçäo imprecisa e distúrbios do ritmo. Recentemente, foram relatados resultados favoráveis através de método de tratamento intensivo e dirigido especificamente para o tratamento da voz na DP, denominado Lee Silverman Voice Treatment (LSVT«). O objetivo essencial desse método é aumentar a intensidade vocal através do incremento do esforço fonatório. O presente estudo teve por objetivo a caracterizaçäo das anormalidades vocais (qualidade vocal, padräo articulatório e inteligibilidade) em um grupo de pacientes com DP e a avaliaçäo da resposta terapêutica obtida pela administraçäo do método Lee Silverman. A comparaçäo dos dados de análise acústica, bem como da análise perceptivo-auditiva nos períodos pré e pós-tratamento mostraram modificações estatisticamente significantes após o tratamento. Embora o padräo articulatório tenha se mantido impreciso, os benefícios obtidos pelo tratamento na melhora da qualidade vocal e, sobretudo, na intensidade vocal favoreceram a qualidade da comunicaçäo oral, reduziram os sintomas negativos e adequaram a qualidade vocal às necessidades pessoais e sociais dos indivíduos