ABSTRACT
Aqueous extract of the stem barks of Croton cuneatus Klotz (Euphorbiaceae) was investigated for hypoglycaemic activity in streptozotocin(STZ)-induced diabetic rats. Increasing doses of aqueous extract (6.5, 13, 26 and 52 mg/kg i.p.) were separately administered to groups of fasted normal and diabetic rats. Plasma glucose concentration, cholesterol and changes in body weight were evaluated. The chronic intraperitoneal (i.p.) administration of the extract for 22 days was found to induce significant reduction in blood glucose level. A comparison was made between the action of the aqueous extract of C. cuneatus and the reference standard drug glibenclamide. The results of this experimental animal study indicate that this plant has an antidiabetic activity in hiperglycaemic rat models.
A ação hipoglicemiante do extrato aquoso das cascas do caule de Croton cuneatus Klotz (Euphorbiaceae) foi investigada em ratos com diabetes induzida pela estreptozotocina (STZ). Doses crescentes do extrato aquoso (6,5, 13, 26 e 52 mg/kg i.p.) foram administradas separadamente a grupos de animais normais e diabéticos em jejum. Foram avaliadas as concentrações plasmáticas de glicose e colesterol, assim como mudanças no peso corporal. A administração crônica intraperitoneal (i.p.) do extrato durante 22 dias induziu uma redução significativa nos níveis de glicose sanguínea. Foi feita uma comparação entre o extrato aquoso de C. cuneatus e a droga de referência glibenclamida. Os resultados desse experimento indicam que esta planta possui atividade antidiabética em modelo com animais hiperglicêmicos.
Subject(s)
Animals , Rats , Croton , Diabetes Mellitus , Hypoglycemia , Plant Extracts , Rats , StreptozocinABSTRACT
In contrast to general medical hospitals, psychiatric hospitals often allow patients to smoke cigarettes. In addition to obvious health concerns, smoking can also interfere with clinical assessments and therapeutic activities, Implementation of a smoking ban on an acute male admissions unit did not result in any increase in aggressive behaviors. In addition, staff attitudes following the ban improved, and most staff members believed the ban was both ethical and beneficial to patients. Our research indicates that banning smoking on an acute admissions unit is feasible and well tolerated by patients and staff, although it may require extra vigilance for smoking-related contraband.
